The Analysis On Related Risk Factors Of Heart Failure Complicated With Complex Ventricular Arrhythmia

ObjectiveTo explore the related risk factors of heart failure(HF)complicated with complex ventricular arrhythmia(CVA),and provide guidance for the early prediction,early intervention and clinical diagnosis and treatment of HF patients complicated with CVA.MethodsThis study selected 303 patients who were diagnosed with heart failure in the Department of Cardiovascular Medicine,Nanfang Hospital of Southern Medical University from January 2019 to August 2022.Collect general clinical data,laboratory test data,cardiac ultrasound examination results and 24-hour ambulatory ECG examination results in patients with HF.According to the 24-hour ambulatory ECG examination results,HF patients with LOWN grades 0-2(No premature ventricular beats,occasional premature ventricular beats,frequent premature ventricular beats(≥30beats/hours))were divided into group A,according to the LOWN grade of premature ventricular contractions,and HF patients with LOWN grades 3-5(Polygenic and polymorphic premature ventricular contractions,paired premature ventricular contractions,short paroxysmal ventricular tachycardia,R on T phenomenon)And persistent ventricular tachycardia,ventricular flutter,ventricular fibrillation were divided into B group.SPSS 26.0 software package was used for statistical analysis,and P<0.05 was regarded as statistically significant.Univariate and multivariate logistic regression analysis was used to explore the related risk factors of HF patients combined with CVA.Receiver operating characteristic curve(ROC)was used to evaluate the predictive value of risk factors in CVA of HF patients.Pearson correlation analysis was used for two continuous variables,and Spearman correlation analysis was used for grading variables.Results(1)Compared with group B,age,heart rate,diabetes,etiology of heart failure,Total triglycerides(TG),C-reactive protein(CRP),total Cholesterol(CHO),High density lipoprotein(HDL),Low density lipoprotein(LDL),Na+,Ca2+,Creatinine(Cr),Uric acid(UA),Heart rate variety(HRV)index,Angiotensin converting enzyme inhibitor(ACEI),Angiotensin Receptor Blocker(ARB),β-blockers,spironolactone,furosemide had no significant difference(P>0.05).There were significant differences(P<0.05)in gender,hypertension,smoking,alcohol consumption,type of heart failure,cardiac function classification,Left ventricular end-diastolic dimension(LVeDd),Left ventricular ejection fraction(LVEF),Left atrial diameter(LAD),Serum N-terminal Pro-brain Natriuretic Peptide(NT-pro BNP),Cardiac troponin(cTn)and K+.(2)Univariate regression analysis showed that there were statistically significant differences in LVEF,LVeDd,LAD,cTn,K+,male,hypertension,smoking,alcohol consumption,heart function grade and heart failure type between group A and group B(P<0.05).(3)Multivariate Logistic regression analysis showed that LVeDd>55mm(OR=2.924,95%CI 1.624-5.264),cTn>0.076 ng/mL(OR=2.379,95%CI 1.106-5.117),K+≤3.5mmol/L(OR=3.741,95%CI 1.714-8.169),hypertension(OR=1.947,95%CI 1.162-3.262),alcohol consumption(OR=2.045,95%CI 1.109-3.769)were statistically significant(P<0.05).(4)ROC curve analysis results showed that the areas under ROC curves of LVeDd,cTn,K+,alcohol consumption and hypertension were 0.702(P<0.001),0.608(P<0.05),0.581(P<0.05),0.582(P<0.05),0.564(P>0.05).ConclusionsLVeDd increased,cTn increased,K+decreased,history of hypertension and Excessive alcohol consumption were potential independent risk factors for predicting.LVeDd,and LVeDd has a high accuracy in predicting CVA in HF patients.