Incidence And Risk Factors Of Recurrent Vertebral Fractures Within One Year After PVP

Objective:To explore the incidence of recurrent vertebral fractures and its related factors by retrospective study of recurrent vertebral fractures within one year after percutaneous vertebroplasty in patients with osteoporotic vertebral compression fractures.Method:The patients with OVCFs in our department from January 2019 to January 2021 were retrospectively analyzed.Combined with the inclusion and exclusion criteria,349 patients were selected.According to whether the patients had recurrent vertebral fractures within one year after PVP,they were divided into recurrent fracture group within one year after PVP and non recurrent fracture group within one year after PVP.The incidence of recurrent vertebral fractures after PVP was calculated.The data of the two groups(general data,laboratory data,imaging and surgical data,etc.)were compared by independent sample t/u-test and X2-test.Univariate analysis and logistic regression analysis were used to find out the risk factors of recurrent vertebral fracture within one year after PVP.Result:A total of 349 patients(468 fractured vertebraes)after PVP were included.The age ranged from 50 to 92 years old,with an average age of 68.57±6.92 years old,including 72 males(20.63%)and 277 females(79.37%).There were 35 cases of recurrent fractures within one year after operation,with an incidence of 10.03%,of which 18 cases were in the high incidence period within three months after operation,accounting for 51.43%of the recurrent fractures within one year after operation.Univariate analysis of cardiovascular and cerebrovascular diseases,hypertension,respiratory diseases,Charlson complication index,postoperative anti-osteoporosis treatment,previous fracture history,erythrocyte sedimentation rate(ESR),fasting blood glucose,albumin,potassium,phosphorus,low-density lipoprotein(LDL),bone turnover markers,recovery rate of anterior vertebral height and the correction degree of angle of local kyphosis was significantly different between the two groups(P<0.05);Multivariate analysis showed that there were significant differences in Charlson complication index,postoperative anti-osteoporosis treatment,ESR,fasting blood glucose,recovery rate of anterior vertebral height and correction angle of local kyphosis angle between the two groups(P<0.05).Conclusion:1.The first 3 months after PVP are the peak period of recurrent vertebral fracture.2.In this study,high Charlson complication index,no postoperative anti-osteoporosis treatment,high ESR,low fasting blood glucose,restoration of anterior vertebral height and correction of local kyphosis angle are the risk factors of recurrent fracture within one year after PVP in OVCFs patients.