| Objective:The clinical characteristics of patients with Neuromyelitis optica spectrum disorder(NMOSD)in southwest Luxian were retrospectively analyzed,the clinical characteristics of patients with NMOSD in this region were clarified,and the influencing factors related to the prognosis of patients in the clinical characteristics of the disease were discussed,so as to provide a basis for the clinical diagnosis and treatment of NMOSD.Methods:1.The medical records of NMOSD patients hospitalized in the Affiliated Hospital of Jining Medical University from January 2015 to June 2021 were collected,and the patients were followed up,and finally74 patients were enrolled,and the medical record data and follow-up data of patients were summarized and analyzed.According to the age of onset,the Early-onset Neuromyelitis optica spectrum disorder(EO-NMOSD)group was compared with the late-onset Neuromyelitis optica spectrum disorder(LO-NMOSD)in the basic clinical features,whether there are differences in laboratory tests,imaging data,prognosis and other aspects;The above data was analyzed using SPSS 26.0 software,and it was statistically significant as P<0.05.2.Firstly,univariate logistic regression was used to analyze the influence of the clinical characteristics of the first onset on the prognosis of patients.Multivariate logistic regression was used to analyze the impact of clinical information such as sex,age,incidence frequency,underlying diseases and autoimmune diseases on the prognosis of patients.Finally,the receiver operating characteristic curve(ROC curve)was used to analyze the prognosis of patients,and its ability to predict patient prognosis was evaluated according to the area,sensitivity and specificity under the curve.Analysis using SPSS 26.0 software,expressed as P<0.05 is statistically significant.Results:1.In terms of basic clinical features,there were significant differences between the EO-NMOSD group and the LO-NMOSD group in the combination of hypertension,coronary heart disease and other underlying diseases(P<0.05).There were no significant differences between the EO-NMOSD group and the LO-NMOSD group in gender,first symptoms,prodromal infection,peak EDSS score,concomitant pain,diabetes mellitus,autoimmune disease,tumor,and surgical history(P>0.05).In terms of laboratory results: there were significant differences between the EO-NMOSD group and the LO-NMOSD group in anti-SSA antibodies,cerebrospinal fluid microalbumin,immunoglobulin A,and immunoglobulin G(P<0.05).There were no significant differences between the EO-NMOSD group and the LO-NMOSD group in blood immunoglobulin,thyroid triathlon,rheumatism,AQP4-Ig G antibody,other autoimmune antibodies,cerebrospinal fluid white blood cell count,cerebrospinal fluid protein quantification,and immunoglobulin A(P>0.05).In terms of imaging: there was a statistically significant difference between the EO-NMOSD group and the LO-NMOSD group in brainstem lesions(P<0.05).There was no significant difference between the EO-NMOSD group and the LO-NMOSD group in other lesions(P>0.05).In terms of recurrence,sequelae,complications,and last EDSS score: there were significant differences between the EO-NMOSD group and the LO-NMOSD group in the sequelae of visual impairment and complications of co-infection(P<0.05).There was no statistically significant difference between the EO-NMOSD group and the LO-NMOSD group in other measures(P>0.05).2.Univariate and multivariate logistic regression was used to analyze the relevant factors affecting prognosis,and it was found that age was the prognostic factor of patients with NMOSD(OR: 1.059,CI:1.071-1.103).The diagnostic value of age analysis in patients with NMOSD was analyzed using ROC.The results showed an AUC of 0.705,a sensitivity of 54.30%,specificity of 80.60%,a Yoden index of 0.389,and a diagnostic efficacy of 57.5.Conclusion:1.Patients in the EO-NMOSD group were more likely to have visual impairment than the LO-NMOSD group,and patients in the LO-NMOSD group were more likely to be co-infected than those in the EO-NMOSD group.2.Age of first onset correlates with prognosis in patients with NMOSD. |
