Based On The Idea Of "State Target Syndrome Differentiation" To Observe The Clinical Efficacy Of Dachaihu Decoction In The Treatment Of T2DM Insulin Resistance(Heat Stagnation Of Liver And Stomach)

Objective: Based on the idea of "state target syndrome differentiation",to observe the clinical efficacy of Dachaihu decoction in the treatment of T2 DM insulin resistance(heat stagnation of liver and stomach),and make a theoretical discussion,expound the clinical characteristics of TCM treatment,in order to provide new ideas and methods for the treatment of T2 DM insulin resistance with traditional Chinese medicine.Methods: A total of 68 patients who met the diagnostic criteri were collected from the outpatient department and ward of the Endocrinology Department of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from March 2021 to October 2022,and randomly divided into experimental group and control group,with 34 cases in each group.The control group was given basic treatment of diabetes and oral metformin tablets.The experimental group was treated with Dachaihu Decoction on the basis of the control group.The treatment course of both groups was 12 weeks.Observe and compare the TCM syndrome scores,blood glucose,blood lipids,insulin resistance index,islets β Cell function index,waist to hip ratio and body mass Index of the two groups before and after treatment.The data were processed and analyzed with statistical software SPSS 27.0.Results: 1.TCM syndrome scores: The TCM syndrome score of both groups decreased after treatment(P<0.01),and the effect of the experimental group is significantly better than that of the control group(P<0.01).2.TCM syndrome effect: The total effective rate of the experimental group was 87.50%,the total effective rate of the control group was 68.75%,and the curative effect of the experimental group is significantly better than that of the control group(P<0.01).3.Blood glucose: After treatment,FBG,P2 h BG and Hb A1 c in both groups were significantly lower than those before treatment.The efficacy of the experimental group in reducing P2 h BG was significantly better than that of the control group(P<0.01).4.Blood lipids: After treatment,TG,TC and LDL-C in both groups were significantly lower than that before treatment(P<0.01),while HDL-C was significantly higher than that before treatment(P<0.01).The efficacy of the experimental group in reducing TG(P<0.05)and TC(P<0.01)was better than that of the control group.5.Islet function: After treatment,FINS and HOMA-IR in both groups were significantly lower than those before treatment(P<0.01),while HOMA-β was significantly higher than that before treatment(P<0.01),but the curative effect was generally the same(P>0.05).6.BMI、WHR: After treatment,BMI and WHR in both groups were significantly lower than those before treatment(P<0.01).The efficacy of the experimental group in reducing BMI was better than that of the control group(P<0.05).7.During the treatment,no discomfort occurred in the two groups,and no obvious abnormality was found in the safety indicators.Conclusion: Dachaihu Decoction can effectively reduce blood glucose,regulate blood lipids,reduce BMI and WHR,reduce insulin resistance,and relieve clinical symptoms of traditional Chinese medicine in the treatment of T2 DM patients with insulin resistance due to stagnation of heat in the liver and stomach.It is safe and worthy of further research and application.