| Objective: To observe the clinical efficacy and safety of modifide xiaoyaosan combined with auricular pressure treatment of depressed liver and deficient spleen type colorectal clinical study of associated depression,and to provide the corresponding clinical experience and theoretical basis for the treatment of colorectal cancer-related depression by integrated Chinese and western medicine in the future.Methods: A total of 96 patients with liver-stagnation and spleen-deficiency type of colorectal cancer-related depression were included in this study and divided into control group and experimental group by random number table method,with 48 patients in each group.The control group was given fluoxetine hydrochloride capsules(Prozac);On the basis of the control group,the experimental group was combined with modifide xiaoyaosan combined with auricular pressure.After two cycles of treatment,the differences of SDS scores,TCM syndrome scores,QLQ-C30 scores,T lymphocyte subsets CD3+,CD4+,CD8+,tumor markers CEA,CA199 detection results and drug safety between the two groups were observed.Through comprehensive analysis,the clinical efficacy and safety of modifide xiaoyaosan combined with auricular pressure combined with fluoxetine hydrochloride were evaluated.Results: After two cycles of treatment,the changes of each observation index are as follows:(1)Efficacy of depression state: after treatment,the effective rate of the experimental group was 71.11%,and the effective rate of the control group was 44.44%,and there was a difference between the two groups(P<0.05).SDS scores after treatment were significantly decreased in both groups compared with before treatment(P<0.01).The SDS score of the experimental group was significantly lower than that of the control group after treatment(P<0.05),which was statistically significant.Further analysis showed that the experimental group of patients female,aged ≥60years old and stage Ⅰ～Ⅱ colorectal cancer patients had better effect(P<0.05).(2)Efficacy of TCM syndromes: the effective rate of the experimental group was 80.00%,and the effective rate of the control group was 40.00%.There was a difference between the two groups(P<0.05).In the experimental group,7 symptoms of discomposure,emotional depression,irritability and loose stool were all relieved(P<0.05),while in the control group,6 symptoms of discomposure,emotional depression,irritability and loose stool were relieved(P<0.05).The scores of experimental groups were lower than those of control group in the aspects of restlessness,emotional depression,irritability and crying,abdominal distension and limb burnout after treatment,with statistical differences(P < 0.05).(3)Quality of life:Overall quality of life and scores of physical function,role function,cognitive function,emotional function and social function of the experimental group were increased after treatment(P<0.05),and scores of fatigue,nausea/vomiting,pain,shortness of breath,insomnia,loss of appetite,constipation and diarrhea were improved(P<0.05);After treatment,the overall quality of life,role function and emotional function scores of the control group were improved(P<0.05),and the individual scores of fatigue,nausea/vomiting,decreased appetite and constipation were improved(P<0.05).The scores of the test group in overall quality of life,emotional function and social function were significantly higher than those of the control group(P<0.05),and the symptoms of nausea/vomiting,pain,decreased appetite,constipation and diarrhea were better than those of the control group(P<0.05).(4)T lymphocyte subsets CD3+,CD4+,CD8+ : the levels of CD3+,CD4+,CD8+ in the experimental group after treatment were significantly different from those before treatment(P < 0.05);After treatment,there were differences in the levels of CD3+ and CD4+ between the experimental group and the control group(P<0.05).(5)Tumor markers CEA and CA199: There were no significant differences between test group and control group in CEA and CA199 after treatment compared with before treatment(P>0.05).There were no differences in CEA and CA199 levels between the two groups after treatment(P>0.05).(6)Adverse reactions: There were no significant abnormal changes in liver and kidney function,hematuria routine,electrolytes and tumor markers in the two groups compared with before treatment,and no test-related adverse reactions were observed.Conclusions: Compared with fluoxetine hydrochloride alone,modifide xiaoyaosan combined with auricular pressure combined with fluoxetine hydrochloride in the treatment of depression associated with liver depression and spleen deficiency,It is more effective in improving depression,relieving clinical symptoms,improving quality of life and enhancing immune function. |
