| Objective: To explore the clinical efficacy of combining Sini powder and Banxia Houpu Decoction in the treatment of Hashimoto’s thyroiditis with qi stagnation and phlegm coagulation type.Methods: The study included 64 eligible patients,who were randomly assigned to a control group and a test group.The control group was treated with Se Yeast Capsule,and the experimental group received Sini powder and Banxia Houpu Decoction for internal use on the basis of general treatment.The total duration of treatment was 3 courses of 4 weeks.The patients in the two groups were scored and the changes in thyroid function(FT3,FT4,TSH),thyroid antibody titres(TGAb,TPOAb)and thyroid ultrasound(thickness of isthmus,left lobe and right lobe)were compared before and after treatment,Statistical analysis was performed with SPSS 26.0.Results: In this study,64 patients were presented,and 1 was eliminated in the control group.Finally,63 patients were enrolled,32 in experimental group and 31 in control group.The results showed that there were no significant differences in gender,age,association or absence of thyroid nodules(P>0.05)between the test and the control group.1.TCM Symptom Score: after treatment,the test group had significant efficacy for each symptom when compared within the two groups(P<0.01).There was a statistically significant difference in the efficacy of the control group in improving the symptom of depression or anxiety(P<0.05),while the others had no significant difference(P>0.05).Compared with the control group,the improvement of all clinical symptoms was obvious in the experimental group(P<0.01).2.TCM evidence and efficiency: In group comparison,the TCM evidence score of the test group was significantly lower than before(P<0.01).while there was no significant difference in the control group(P>0.05).Compared with the control group,the experimental group was obviously superior to the control(P<0.01).3.Thyroid antibody titers: In group comparison,the serum levels of TGAb and TPOAb were obviously decreased in the test group(P<0.01).However,there was no significant difference in serum TPOAb in the control group(P<0.05),and there was no statistical difference in TGAb(P>0.05).Compared with the control group,the test group was superior(P<0.05).4.Thyroid Ultrasound: In the intra-group comparison between the two groups before and after treatment,the degree of reduction in the thickness of the isthmus,left lobe and right lobe of the thyroid gland was statistically significant in the test group(P<0.01),while the difference in the control group was not statistically significant(P>0.05).Compared with the control group after treatment,the left lobe was significantly improved(P<0.01),and the right lobe and the isthmus were significantly improved(P<0.05).5.Thyroid function: There were no statistically significant differences in serum FT3,FT4 and TSH levels between the two groups after treatment,both within and between groups(P>0.05).6.Clinical efficacy: the efficacy rate of Chinese medicine symptoms in the test group was 87.5% and the comprehensive clinical efficacy was62.5%;the efficacy rate of Chinese medicine symptoms and the comprehensive clinical efficacy in the control group both was 25.8%,and The experimental group and the control group were significantly different(P<0.01).Conclusion: The combination of combining Sini powder and Banxia Houpu Decoction has good clinical efficacy in reducing the autoantibody titer of the thyroid gland and reducing the thickness of the thyroid gland in patients with Hashimoto’s thyroiditis with qi stagnation and phlegm coagulation type,and has a significant effect on the relief of patients’ discomfort.There are no adverse effects on serum FT3,FT4 and TSH levels during the dosing period,no significant adverse reactions,the dosing is safe and reliable and worthy of clinical promotion. |
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