| Objective A variety of cancers occur directly or indirectly driven by inflammation,and chronic inflammation can also promote further cancer progression.In this study,we investigated the relationship between LTE4 level,ALDH2 and smoking and alcohol consumption with the onset and progression of esophageal squamous cell carcinoma,and some dynamic links established between various factors of inflammation in the body by correlating plasma LTB4,urine LTE4 and each cell level in blood and urine routine in patients with esophageal squamous cell carcinoma,and investigating their daily living habits,aiming to provide a basis for the clinical The aim is to provide a basic research basis for the clinical diagnosis,treatment and effective prevention of esophageal cancer.Methods A single-center,prospective clinical randomized controlled study was conducted to detect changes in plasma LTB4 and urinary LTE4 levels by double antibody sandwich ELISA in 115 randomly selected patients diagnosed with esophageal cancer without other comorbidities in the oncology ward between May 2021 and May 2022;rs671 mutation in the Acetaldehyde dehydrogenase II(ALDH2)gene of esophageal cancer was also detected by Taqman probe;and all data were statistically analyzed by statistical software.Results1.In the 115 patients with esophageal cancer enrolled,the age of prevalence was around 60 years old,and men were significantly higher than women.2.The level of LTB4 in the blood of 87 esophageal cancer patients was significantly lower than that of the control group(P<0.001);the LTE4 in the urine of 50 esophageal cancer patients was significantly higher than that of the control group(P<0.0001),but no significant change was seen in the WBC in urine(P>0.05).3.RBC,HGB,HCT,PLT,Lym%,and Lym in the blood of 115 patients with esophageal cancer were significantly lower than those in the control group(P<0.0001);although Neu% and M% were both elevated compared with the control group,and the elevation of M%(P<0.001)was more significant than that of Neu%(P<0.05),but no significant differences were seen in WBC,Neu,and M compared with the control group(P>0.05).NLR and MLR were significantly higher(P<0.001),while PLR was significantly lower(P<0.001)in patients with can esophageal cancer compared with the control group.4.LTB4 was correlated with RBC,HGB,Lym%,Lym,Neu% and MLR,among which it was negatively correlated with RBC and HGB,and positively correlated with Lym%,Lym,Neu% and MLR.5.The occurrence of esophageal cancer was closely correlated with poor lifestyle habits such as smoking and alcohol consumption(P<0.05);the age of onset of ESCC patients who smoked one or more packs per day was significantly earlier than that of nonsmoking patients and patients who smoked less than one pack per day(P<0.05),and the age of onset of ESCC patients who drank alcohol regularly or were frequently drunk was significantly earlier than that of nondrinking patients(P<0.05),and the age of onset of ESCC patients who drank occasionally or a small amount of There was no significant difference(P>0.05)between patients with occasional or small amount of alcohol consumption;moreover,the mean age of those with rs671 acetaldehyde dehydrogenase locus genotype GA was significantly lower than that of those with GG frequent alcohol consumption in patients with esophageal cancer who drank frequently.In particular,a total of 5 patients with ESCC onset age below45 years old,3 of whom had both Acetaldehyde dehydrogenase rs671 mutation and regular alcohol consumption and smoking habit.The correlation between the mutation of ALDH2 rs671 gene locus and smoking and drinking habits and the age of ESCC onset was significantly negative(P<0.01).Conclusions1.The level of urinary LTE4 and the level of systemic inflammatory response indexes NLR,MLR and PLR were statistically correlated with the occurrence of esophageal squamous cell carcinoma,which may be involved in the occurrence of esophageal carcinoma,but the specific mechanism needs further study and exploration.2.The superposition of mutation of ALDH2 rs671 locus and the poor lifestyle habits of smoking and drinking may be an important reason for the early onset of esophageal squamous cell carcinoma... |
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