Effects And Related Studies Of Helicobacter Pylori Infection On Colorectal Polyps

Objective:To analyze and investigate the Helicobacter pylori（Hp）infection and other potential influencing factors in colorectal polyp patients,and explore the relationship between Hp infection and the clinical characteristics of colorectal polyp colonoscopy,in order to provide reference for the prevention and treatment of clinical colorectal polyps.Methods:Adopting the method of the retrospective analysis method,determining the inclusion criteria and exclusion criteria,continuously collecting patients diagnosed with colorectal polyps by colonoscopy and pathological biopsy diagnosed who were selected in the Department of Gastroenterology of Dalian Central Hospital from January 2022 to December 2022,and the physical examination patients who confirmed that there were no colorectal polyps during the same period.The ¹⁴C breath test(¹⁴C-UBT)and the Rapid Urease Test（RUT）were used to detect Hp infection.General information such as age,sex,body mass index（BMI）and other general information of all enrolled patients,past history of hypertension,diabetes,Total Cholesterol（TC）,Triglycerides（TG）,glucose（GLU）,homocysteine（HCY）and other laboratory indicators of all patients were counted at the same time.Univariate analysis was used to compare the differences between the above indicators between the two groups,and the statistically significant indicators were further included in multivariate logistic regression,to analyze the relationship between colorectal polyps and all indicators,including Hp infection status.On this basis,according to the status of Hp infection,colorectal polyp patients were divided into 238cases in the Hp-positive group and 199 cases in the Hp-negative group,and the colonoscopy data of the two groups were recorded in detail,and the relationship between Hp infection and colorectal polyp patients’polyp size,polyp number,polyp location and polyp pathological type was statistically analyzed.Results:A total of 437 patients with a mean age of（61.74±9.59）years old were included in this study.There were 200 people in the control group,with an average age of（60.37±8.16）years old.There were 251（57.4%）males and 186（42.6%）females in the case group,70 males（35.0%）and 130（65.0%）females in the control group.The risk of colorectal polyps was higher in men than in females（P<0.05）.The Hp infection rates in the case group and control group were 54.5%（238/437）and 40.0%（80/200）,respectively,and the difference was statistically significant（P<0.05）.In addition,BMI,history of hypertension,GLU,TG,and HCY were also associated with the occurrence of colorectal polyps,and the difference was statistically significant（P<0.05）.The further multivariate logistic regression analysis found that gender（OR=2.260,95%CI:1.568～3.258,P<0.05）,Hp infection（OR=1.545,95%CI:1.082～2.208,P<0.05）can still be used as independent risk factors affecting the occurrence of colorectal polyps after excluding the interference of clinical information such as patient age.The Hp infection status of colorectal polyps was related to polyp size（P=0.004）,polyp number（P<0.001）,and pathological classification of polyps（P=0.008）.There was no significant difference in association with polyp location（P>0.05）.Conclusion:1.Hp infection,male,BMI,hypertension,GLU,TG,and HCY are associated with the development of colorectal polyps.2.Hp infection is an independent risk factors for colorectal polyps.3.The patients who suffer from colorectal polyps merging with Hp infection,the colonoscopy appearance is larger and multiple,and the pathological classifications are mostly adenomatous polyps.Therefore,the patients with colorectal polyps need to pay attention to the prevention of Hp infection.