| Background: Laryngeal carcinoma is a primary malignant tumor originating from the laryngeal mucosa,and its pathogenesis is not fully understood.It is a rare cancer and,unfortunately,throat cancer is one of the few oncological diseases whose 5-year survival rate has declined over the past 40 years,from 66% to 63%,although the overall incidence is declining.This highlights the need for further research and innovation in this field.Foremost among them is tobacco and alcohol consumption.Tobacco use has been shown to be linearly associated with the development of throat cancer,with smokers having a 10 to 15 times higher risk than non-smokers and up to 30 times the risk in the heaviest smokers.In clinical practice,uncontrolled micro RNAs are frequently observed in laryngeal cancer patients.In recent years,an increasing number of studies have confirmed the powerful biomarker potential of micro RNAs(miRNAs).We performed a systematic review and meta-analysis to identify and highlight multiple micro RNAs as biomarkers for disease prognosis in laryngeal cancer patients.Methods: The three subject terms retrieved were laryngeal cancer,micro RNA,and prognosis.According to the combination of subject headings and free words,we searched Pub Med,Embase,Web of Science and Cochrane Library databases in turn,and checked by checking the title,abstract and downloading the full text to find the articles that match this research,and put these articles in into the Endnote document manager.A total of 5307 laryngeal cancer patients were included in this study to assess the association between miRNA expression levels and patient prognosis.According to the expression level,miRNAs were divided into up-regulated and down-regulated groups.The prognosis of these two groups was investigated to obtain a pooled forest plot.Then,group discussions were conducted according to the type of miRNA and the selection of survival endpoints to find the source of heterogeneity.For clinical-stage overall survival,hazard ratios(HR)and corresponding 95% CIs were calculated to assess the effect of survival.Results: A total of 36 studies on miRNAs and laryngeal cancer prognosis were included in this meta-analysis;selected endpoints for these studies included overall survival(OS)and disease-free survival(DFS).The comorbidities of high and low expression of miRNAs were 1.13(95% CI 1.06-1.20,P < 0.05)and 1.10(95% CI 1.00-1.20,P <0.05),respectively.Conclusion: The results show that miRNA,as a prognostic biomarker of laryngeal squamous cell carcinoma,plays an important role in clinical value,and can provide clinicians with help in diagnosis and decision-making.In particular,miR-100,miR-155,miR-21,miR-34 a,miR-195 and miRNA-let-7 have potential as prognostic biomarkers.However,further large-scale cohort studies based on these miRNAs are urgently needed to validate their clinical value and help determine the direction of future clinical work in this field. |
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