Research On Professor Wei Wei’s Medication Law For Functional Constipation Based On Data Mining

Objective: Through data mining technology,this paper retrospectively studied the outpatient medical record information of Professor Wei wei in the treatment of functional constipation,discussed and summarized the drug characteristics of Professor Wei wei in the treatment of functional constipation,condensed the related clinical characteristics and academic thoughts of Professor Wei wei in the treatment of the disease,in order to provide new clinical ideas and methods.Methods: The outpatient medical records of functional constipation treated and treated by Professor Wei wei from January 2019 to December2022 were collected.According to the inclusion and exclusion criteria,a total of 60 patients meeting the requirements were screened out for 104 medical records.The complete information of medical records was normalized and a database was established.By means of TCM inheritance computing platform V2.5(TCMICS V2.5)software and Office Excel 2019,statistical analysis,association rule analysis and cluster analysis were carried out on the medical record data in the database,and the characteristics of medication used by Professor Wei wei for the treatment of functional constipation were summarized,so as to further explore Professor Wei wei’s academic thoughts on the treatment of the disease.Results:1.In this study,there were 18 male patients and 42 female patients,with a male-female ratio of 1:2.3.The minimum age is 18 and the maximum age is 87.Patients aged 20-29 years and 50-59 years accounted for 25% of the total patients.2.104 prescriptions were included in this study,and 123 traditional Chinese medicines were used,with a total of 1556 times of application.There were 12 kinds of drugs used more than 50 times(Radix paeoniae alba,magnolia officinalis,licorice,poria cocos,Radix rehmanniae,Rhizoma coptidis,ophiopogon ophiopogon,Fructus aurantii,rhubarb,areca areca,Radix officinalis,Radix scrophulariae),which were used 761 times,48.91%of the total drug frequency.The main drug efficacy categories were deficiency supplementing,heat clearing,qi regulating,dampness removing and diarrhea.Among them,qi supplementing was the most frequently used deficiency supplementing drug,with 191 times in total,54.39% of the deficiency supplementing drugs.The high use of drug properties were cold,warm and flat,and the highest use frequency was cold drugs.The high frequency of use of medicinal flavor is sweet,bitter,hot taste.Drugs to spleen meridian,stomach meridian,lung meridian,heart meridian,liver meridian,kidney meridian,large intestine meridian.3.Drug association analysis: When the number of support degree was set to 40 and confidence level was set to 0.7,56 groups of core drug combinations,96 drug association rules and 13 types of core drugs were obtained(Paeonia lactis,glycyrrhiza licorice,magnolia officinalis,Coptis chinensis,xylosa,poria cocos,Aurantium aurantium,Radix scrophulariae,Radix rehmanniae,ophiopogon ophiopogon,areca nut,Wuzhuyu officinalis,rhubarb).By drug cluster analysis,5 groups of drug core combinations were obtained which were consistent with the clinical practice: C1 magnolia officinalis,poria cocos,Rehmannia officinalis,Paeoniae alba,rhubarb and Fructus aurantii.C2 Licorice,Paeony,Radix rehmanniae,Magnolia officinalis,Yuzhu,Astragalus;C3 licorice,Magnolia officinalis,Fructus aurantii,Rhizoma coptidis,aconitum,xylosa;C4 Coptidis,Wuzhuyu,areca,Poria,atractylodes,Xylosa;C5 Fire sesame seed,Yuzhu,codonopsis codonopsis,Rehmannia,Ophiopogonis ophiopogonis,Scrophulariae.Conclusion(s):1.Professor Wei wei’s core high-frequency drugs for the treatment of functional constipation include: Paeonia lactis,Magnolia officinalis,licorice,poria cocos,Radix rehmanniae,Rhizoma coptidis,ophiopogon,Fructus aurantii,rhubarb and areca nut.2.The efficacy categories of the drugs commonly used by Professor Wei wei in the treatment of functional constipation are deficiency tonic drugs,heat clearing drugs,qi regulating drugs and dampness removing drugs.Commonly used drugs are cold,warm,flat,sweet,bitter,xin,spleen,stomach,lung,heart,liver,kidney.3.In the treatment of functional constipation,Professor Wei wei uses the combination of sweet,bitter and xin,cold and temperature.The basic method is to regulate the spleen and stomach,and regulate the qi and organs of the intestine.The treatment focuses on the moistening of Yin and blood and the promotion of Yang qi.