In Vitro Experimental Study Of The Hemodynamic Effects Of Microsurgical Clipping On The Environment Of The Parent Artery

Objective:To establish an aneurysm model based on DSA data using hemodynamics simulation technology,and to compare the hemodynamic characteristics before and after clipping;Based on this model,3D printing technology was used to print the silica gel model of the model,and the morphological changes and hemodynamic changes of the two were compared.Methods:The DSA data of patients with intracranial aneurysms before and after operation were extracted with Geomagic software,and three-dimensional solid reconstruction was performed.The model of the patient before and after operation was simulated with ANSYS CFX software,and the hemodynamic characteristics between the two were analyzed.For a patient with an aneurysm at the M1 bifurcation of the left middle cerebral artery,DSA was performed to obtain a three-dimensional vascular model of its true shape.Based on this model,3D printing technology was used to obtain the same 3D printing silica gel model,and the 3D printing model was DSA to obtain a three-dimensional solid model.The two models are divided into CFD grids,and further simulated by CFX to analyze their morphology and hemodynamic results.Results:Through simulation,the WSS of the aneurysm area after clipping was higher than that before surgery,and the wall pressure was significantly lower than that before surgery;Surgical clipping of aneurysms improves the previously complicated and disordered blood flow pattern and evenly distributes the downstream branch arteries.By comparing the morphology of the 3D printed silica gel model with the real model,it was found that the size and orientation of the aneurysm were basically the same,and the shape of the branch vessels and the smoothness of the vessel wall were different.The hemodynamic parameters,WSS,wall pressure and blood flow streamline distribution between the two are very similar.Conclusion:Aneurysm clipping can improve the blood flow velocity,blood flow pattern.wall shear stress and wall pressure in the parent artery.In addition,the aneurysm clip can maximize the reinforcement of the position of the largest stress on the aneurysm neck,and prevent the growth and recurrence of the aneurysm.3D printed silica gel aneurysm model can be applied to preoperative simulation to find the best clamping method for patients.