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Robotic Versus Open Extended Cholecystectomy For T1a-T3 Gallbladder Cancer:A Matched Comparison

Posted on:2024-04-22Degree:MasterType:Thesis
Country:ChinaCandidate:J YangFull Text:PDF
GTID:2544307064465094Subject:Clinical Medicine
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Purpose:The feasibility and safety of robotic extended cholecystectomy(REC)are still uncertain.This study was performed to compare the short-and long-term outcomes of REC with those of open extended cholecystectomy(OEC)for T1a-T3 gallbladder.Methods:From January 2015 to April 2022,28 patients underwent REC in our center.To minimize any confounding factors,a 1:2 propensity score-matching analysis was conducted based on the patients’ demographics,liver function indicators,T stage,and symptoms.The data regarding demographics,perioperative outcomes,and long-term oncologic outcomes were reviewed.Results:The visual analogue scale score was significantly lower in the REC than OEC group immediately postoperatively(3.68±2.09 vs.4.73±1.85,P=0.008),on postoperative day 1(2.96±1.75 vs.3.69±1.41,P=0.023),and on postoperative day 2(2.36±1.55 vs.2.92±1.21,P=0.031).In addition,the REC group exhibited a shorter time to first ambulation(P=0.043),a shorter time to drainage tube removal(P=0.038),and a shorter postoperative stay(P=0.037),but hospital costs were significantly higher in the REC group(P<0.001).However,no statistically significant difference was found in the operation time(P=0.134),intraoperative blood loss(P=0.467),or incidence of postoperative morbidity(P=0.227)or mortality(P=0.289)between the REC and OEC groups.In regard to long-term outcomes,the 3-year disease-free survival rate was comparable between the OEC and REC groups(43.1% vs.57.2%,P=0.684),as was the 3-year overall survival rate(62.8% vs.75.0%,P=0.619).Conclusions:REC can be an effective and safe alternative to OEC for selected patients with T1a-T3 gallbladder cancer with respect to short-and long-term outcomes.
Keywords/Search Tags:gallbladder cancer, extended cholecystectomy, robotic surgery, propensity score matching, surgical outcomes
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