Research On Neural Change Mechanism After Lower Limb Amputation Based On EEG

Amputation abruptly cuts the afferent and efferent nerves that control the limb,triggering a cascade of remodeling throughout the brain.At the same time,brain remodeling is also thought to be closely related to phantom limb pain.Studying the brain remodeling induced by lower extremity amputation can help to explore the neural mechanism of amputation-related pain.Moreover,by exploring the impact of brain remodeling on motor imagery,it provides a theoretical basis for brain-computer interfaces to improve the lives of amputee patients.This study explored brain function remodeling in lower limb amputee patients from the aspects of task state(motor imagery)and resting state brain function.The paper collected the motor imagery EEG data of patients with unilateral lower limb amputation and the control group,investigated the impact of amputation on motor imagery brain function activities through time-frequency analysis,and analyzed the correlation between abnormal pain and motor imagery rhythm.At the same time,the resting-state EEG data of patients with lower extremity amputation and the control group were collected,and the amputation-related brain function remodeling was analyzed through changes in brain functional connectivity.In the task state,when the amputee performed the motor imagery task,multiple frequency bands showed obvious ERD phenomenon,while the amputee showed obvious ERS phenomenon in the mu frequency band.And,the power of amputee patients was significantly higher than that of healthy controls.In the amputation group,phantom pain was negatively correlated with the power of sensorimotor rhythm and amputation duration.In terms of resting-state brain networks,functional connectivity in sensorimotor rhythms was significantly lower in amputee patients compared with healthy controls.In summary,using high-resolution EEG equipment technology,we explored the brain remodeling of lower limb amputee patients from two aspects of task state and rest state,and found the influence of phantom limb pain on motor imagery.At the same time,changes in functional connectivity in sensorimotor rhythms in amputee patients were also found after amputation.Paper reveals association between phantom limb pain and length of amputation.These results mark the impact of brain remodeling on motor imagery and the resulting alterations in functional connectivity within the brain.The content of this study expands on the association of amputation-related brain remodeling with motor imagery and highlights the importance of sensorimotor rhythms.