Correlation Analysis Of The Effect Of Areca Nut Chewing On Recurrence And Progression Of Non-muscular Invasive Bladder Cancer

Objective:To investigate the effect of areca nut chewing on recurrence and progression of non-muscular invasive bladder cancer.Methods:Clinical case data of 225 patients with non-muscular invasive bladder cancer in the department of Urology of our hospital were retrospectively analyzed from January 2012 to January 2017.The factors included gender,age,hypertension,diabetes,smoking,areca nut chewing,tumor number,tumor diameter,tumor base,pathological stage,pathological grade,concurrent CIS and prior recurrence condition.Survival analysis,including univariate analysis and multivariate analysis,was carried out by employing Kaplan-Meier and COX proportional hazard model.Results:The recurrence rate was 33.3%(75/225)and the mean recurrence-free survival was 30.0 months.The progression rate was 14.7%(33/225)and the mean progression-free survival was 33.0 months.Univariate analysis showed that smoking,tumor number,tumor diameter,tumor base,pathological stage,pathological grade and prior recurrence condition were the risk factors associated with tumor recurrence(P<0.05),while areca nut chewing,pathological stage,pathological grade,concurrent CIS and prior recurrence condition were the risk factors associated with tumor progression(P<0.05).There were no significant differences between gender,age,hypertension,diabetes and tumor recurrence and progression(P>0.05).Selected statistically significant factors for COX regression model multivariate analysis showed that smoking,tumor number,tumor diameter,tumor base,pathological stage,pathological grade and prior recurrence condition were the independent risk factors for the recurrence of non-muscular invasive bladder cancer.Areca nut chewing,pathological stage,pathological grade,concurrent CIS and prior recurrence condition were the independent risk factors for the progression of non-muscular invasive bladder cancer.Conclusion:Smoking,tumor number,tumor diameter,tumor base,pathological stage,pathological grade and prior recurrence condition were the independent risk factors for the recurrence of non-muscular invasive bladder cancer.Areca nut chewing,pathological stage,pathological grade,concurrent CIS and prior recurrence condition were the independent risk factors for the progression of non-muscular invasive bladder cancer.