Correlation Between Sodium And Potassium Excretion And Psoriasis Vulgaris And Its Severity

Background:High sodium intake was found to increased helper T(T_H17)cells differentiation.T_H17 cell plays an important role in the process of psoriasis.However,there is a lack of epidemiological studies of the relationship between the daily salt intake and psoriasis.Objective:This study aims to examine the relationship between urine sodium,urine potassium,urine sodium-potassium ratio,daily salt intake and psoriasis and its severity.Methods:This study was a case-control study.The case group included were newly diagnosed with psoriasis vulgaris in the department of dermatology,xiangya hospital,central south university.Meanwhile,the healthy control group were matched according to sex and age,and without psoriasis in public officials in the Hunan province cohort.The demographic and clinical data of the participants were collected by investigators.Then,we collected the random urine(random urine group)or 24-hour urine(24-hour urine group)of the participants.Urine biomarkers were measured through standardized clinical procedures.Finally,the relationships between urinary sodium,urinary potassium,urinary sodium-potassium ratio,and daily salt intake and psoriasis and its severity were analyzed.We used logistic regression to analyze the associations of urine parameters,daily salt intake and psoriasis and its severity.A cubic spline function was used to considered the nonlinear relationship between continuous independent variables and dependent variables.Results:In the random urine group,52 psoriasis patients and 156healthy controls were included.And in the 24-hour urine group,74patients with psoriasis and 38 controls were included.(1)In the study on the relationships between urine sodium,urine potassium,urine sodium-potassium ratio,daily salt intake and psoriasis,the results showed that the estimated daily salt intake of psoriatic patients was higher than the healthy controls;The estimated daily salt intake showed a dose-dependently relationship with the case composition ratio of psoriasis;One-gram increment in the 24-hour urine estimated daily salt intake was associated with a 1.367-fold(95%CI:1.173-1.594)risk of psoriasis.The risk of psoriasis in the random high urine sodium-potassium ratio group was 3.651-fold(95%CI:1.327-10.050,P=0.012)that the low sodium-potassium ratio group;And the risk of psoriasis in the 24-hour high urine sodium group and the 24-hour urine estimated high daily salt intake group was 7.718-fold(95%CI:2.840-20.969,P<0.001)than the low urine sodium group and the low daily salt intake group.(2)In the study on the relationships between urine sodium,urine potassium,urine sodium-potassium ratio,daily salt intake and the severity of psoriasis,it was found that no significant correlation between urine sodium,urine potassium,urine sodium-potassium ratio and daily salt intake and the severity of psoriasis.Conclusion:The daily salt intake of psoriasis patients was higher than healthy controls;Daily salt intake were positively correlated with the risk of psoriasis,while daily salt intake was no significant correlated with the severity of psoriasis.Reducing daily sodium intake may have positive implications for reducing the risk of psoriasis.