Wilson Disease Syndrome Combined With Renal Damage And Its Correlation With Clinical Indicators

Objective:Through the clinical observation of patients with hepatomegaly(WD)kidney damage,we explored the distribution characteristics of TCM evidence of WD kidney damage and the relationship between its related influencing factors and clinical indicators,so as to enrich the connotation of modern evidence of WD kidney damage and provide clinical basis and foundation for TCM theoretical research on prevention and treatment of kidney damage caused by WD.Method:The Chinese medicine clinical evidence observation form for hepatomegaly renal damage was developed,and 120 inpatients with WD renal damage who met the inclusion criteria were collected,and the clinical data of the patients were perfected and the evidence observation form was completed.The corresponding database was constructed,and the data were collated using SPSS26.0 statistical analysis software to summarize the distribution of different types of TCM symptoms in patients with WD renal impairment and to explore their correlation with general data and clinical indicators.Result:(1)Basic data of WD patients with renal impairment:among the 120 WD patients with renal impairment in this clinical study,61(50.8%)were male and 59(49.2%)were female.The minimum age of the patients was 3 years,the oldest is 66 years,the mean age was 28.23±11.70 years,and the WD renal impairment patients were mainly between 18 and 45 years,totaling 87(72.5%).By X~2test,the gender composition of WD renal impairment patients at different ages was not significant(P>0.05).According to the age distribution,the proportion of WD renal impairment patients in different age groups ranged from high to low,successively from 18 to 45 years old,13 to 17 years old,46 to 69 years old,and 3 to 12 years old.(2)Distribution characteristics of WD kidney injury syndrome:Of the total of 120patients with WD kidney injury collected in this study,64 cases were vague in speech(53.33%)、Limb tremor occurred in 62 cases(51.67%)、Darkness 36 cases(30.00%)、33 cases were angular salivation(27.5%)、24 cases were Motion clumsy(20.00%)、22 cases were Epistaxis epistaxis(18.33%)、21 cases were bucking(17.50%)、20cases were Instability of gait(16.67%)、14 cases were Sepsis of limbs(11.67%)、12 cases were lags in response(10.00%)、12 cases were Irritable and irritable(10.00%)、9 cases were Urine red(7.5%)、8 cases were abdominal pain(6.67%)。The tongue elephant mainly includes:56cases were red tongue(46.67%)、54cases were Moss yellow greasy(45.00%)、46cases were Moss thin greasy(38.33%)、42cases the tongue were dark and had bruises(35.00%)、12 cases were Moss white(10.00%)。The pulse is mainly present:36cases were wiry and rolling pulse(30%)、29cases were Pulse number(24.17%)、18cases were Pulse string astringent(15%)、The number of veins were 11cases(9.17%)、The pulse string count were 12 cases(10%)。The proportion of different syndrome distribution was 50(41.67%)of damp heat,39(32.5%),16(13.3%)of liver and kidney Yin deficiency.33%),9 cases of liver qi stagnation(7.5%),and 6 cases of spleen and kidney Yang deficiency(5%).(3)Correlation between WD renal damage syndrome and related factors and clinical indicators:In this study,the difference in age distribution of different syndrome was statistically significant(P<0.05),and the mean age of patients with liver and kidney Yin deficiency was significantly greater than that of other syndrome(P<0.05).The difference in gender composition was not statistically significant between TCM syndrome cases of 120 patients in this study.After statistical analysis of blood test index data and TCM syndrome in 120 WD renal damage patients,the results showed significant differences in Cys C and Cr levels between different TCM syndrome(P<0.05).In terms of urinanalysis indexes,the differences between Uβ2-MG,Uα1-MG,and URBP were statistically significant(P<0.05).(4)WD kidney damage Logistic regression:Age,Cys C,Uβ2-MG,Uα1-MG,URBP were related with the presence of simultaneous liver and kidney deficiency(P<0.05),while other indicators had no obvious correlation with the presence of simultaneous liver and kidney deficiency(P>0.05).Men>18 years were more likely to have simultaneous liver and kidney deficiency,the higher the possibility of simultaneous URBP.Conclusion:1.The number of male patients with WD kidney damage is higher,and young and middle-aged people are the most prevalent group of this disease.2.Damp and heat intrinsic syndrome is the most common TCM syndrome of WD kidney damage,followed by phlegm and blood stasis mutual knot syndrome,liver and kidney Yin deficiency syndrome,liver qi stagnation syndrome,spleen and kidney Yang deficiency syndrome.3.The higher the Age、Cys C、Uβ2-MG、Uα1-MG、URBP,the higher the likelihood of liver-kidney yin deficiency.