| Objective:To observe the clinical efficacy of acupoint application combined with liraglutide in the treatment of obese type 2 diabetes mellitus with damp-heat accumulation syndrome,and to comprehensively evaluate its safety,so as to provide new ideas for the treatment of obese type 2 diabetes mellitus with damp-heat accumulation syndrome in the future.Methods:A total of 80 outpatients and inpatients were observed from December2021 to December 2022 at the Department of Endocrinology,Cangzhou Zhongxiyi Medical Clinic.All patients met the inclusion criteria and were randomly divided into 40 treatment and 40 control groups using SPSS 26.0.In the control group,liraglutide was used in addition to conventional baseline treatment,while in the treatment group,a homemade cream was applied to acupuncture points in the Chinese medicine preparation room at West Medicine Hospital of Cangzhou Traditional Chinese Medicine,Hebei.After four weeks as one course and after 12 weeks and three courses,fasting blood glucose(FPG),2-hour postprandial blood glucose(2h PG),glycated haemoglobin(Hb A1 c)and insulin resistance index(IR,body weight,insulin resistance index)were compared in both groups.Hb A1(Homa-IR),body weight(W),body mass index(BMI),waist circumference(WC),cholesterol(TC)and triacylglycerols(TG),low-density lipoprotein(LDL-C)and high-density lipoprotein(HDL-C),evidence values for herbal medicines,side effects were assessed during the study to detect discontinuations and adverse events,and finally the results were analysed using SPSS26.0software.Analysis.Results:1.comparison of glucose metabolism: In the within-group comparison,FPG,2h PG,Hb A1 c and Homa-IR improved in the treatment group and the control group after treatment(P < 0.05);in the between-group comparison,the treatment group improved FPG,2h PG,Hb A1 c and Homa-IR better than the control group(P < 0.05).2.comparison of blood lipids: in both groups,TC,TG,LDL-C and HDL-C improved compared to pre-treatment values(P< 0.05).Compared to the control group,the treatment group had a more significant effect on TG levels(P < 0.05)and there was no statistical significance in the improvement of TC,LDL-C and HDL-C levels(P > 0.05).3.comparison of body weight,waist circumference and BMI: Comparing the two groups,W,WC and BMI decreased after treatment compared with those before treatment(The effect of W,WC and BMI in the treatment group was better than those in the control group at the end of the observation period(P< 0.05).4.comparison of the evidence of Chinese medicine and efficacy scores: In terms of Chinese medicine evidence,the efficacy rate of the treatment group was 95% and that of the control group was 68.42%,and in terms of clinical efficacy,the efficacy rate of the treatment group was 90%and that of the control group was 73.68%.In the within-group comparison,TCM syndrome scores decreased in both the treatment and control groups after treatment;in the between-group comparison,the treatment group improved TCM syndrome better than the control group(P < 0.05).5.10 adverse effects occurred during the observation period,including 8 cases in the control group(2 cases of nausea,2 cases of diarrhoea and 4 cases of anorexia)and 2 cases in the treatment group(anorexia),all of which were tolerable and resolved after 4 weeks.The treatment group was superior to the control group in terms of the occurrence of side effects(P< 0.05).Conclusions:1.Traditional Chinese medicine acupoint application combined with liraglutide in the treatment of obese patients with type 2 diabetes mellitus with damp-heat accumulation syndrome improved their blood glucose and blood lipid levels,reduced their weight,and reduced their waist circumference and BMI.2.Traditional Chinese medicine acupoint application combined with liraglutide in the treatment of obese type 2 diabetes mellitus with damp-heat accumulation syndrome reduces the incidence of clinical adverse reactions,improves the quality of life of patients,and can be applied to clinical practice. |
