A Meta-analysis Of The Relationship Between Blood And Mild Cognitive Impairment In The Elderly

Objective: Objective to systematically review the relationship between blood lipids and mild cognitive impairment(MCI)in the elderly.Methods: By searching the commonly used Chinese and English databases,we collected the data of total cholesterol(TC),triglycerides(TG),high density lipoprotein(HDL)and low density lipoprotein(LDL)of the elderly with MCI and the elderly with normal cognition as of December 20,2020 in Chinese and English.According to the inclusion and exclusion criteria of related literatures and other influencing factors,two professional researchers independently screened out the literatures related to this project.After comprehensively considering the quality of each article and extracting the required relevant information,the Review Manager 5.3software was used,The information and data are analyzed statistically.Results:A total of 27 articles,including 6 English articles and 21 Chinese articles,were included in this meta-analysis,with a total of 8,931 participants.26 articles described the correlation between TC and MCI,27 articles described the correlation between TG and MCI,26 articles described the correlation between HDL and MCI,and 26 articles described the correlation between LDL and MCI.Finally,random effects model was used for meta-analysis.The results showed that there were significant differences in TC(SMD = 0.55,95% CI: 0.38-0.73,P < 0.00001),TG(SMD = 0.37,95% CI: 0.15-0.59,P = 0.001),LDL(SMD = 0.54,95% CI: 0.33-0.75,P < 0.00001)and HDL(SMD =-0.35,95% CI:-0.53-0.17,P = 0.0001)between MCI group and normal cognitive group;that is,MCI was significantly higher than normal cognitive group in TC,TG and LDL The level of HDL in MCI group was significantly lower than that in normal cognitive group.Conclusions:Among the risk factors for the incidence of MCI in the elderly,in addition to being related to higher levels of TC,TG and LDL,lower levels of HDL may also lead to the generation of MCI in the elderly.That is,one of the independent risk factors for MCI in the elderly may be abnormal lipid levels.