Clinical Features And Prognosis Of Patients With Malignant Tumor Complicated With Pulmonary Embolism

RESEARCH OBJECTIVESCancer-associated venous thromboembolism,as the second leading cause of death in cancer patients,threatens the quality of life of patients with malignant tumors.With the continuous improvement of diagnostic techniques,the detection rate of malignant tumors combined with pulmonary embolism has increased.Early intervention effectively promotes prognosis.By exploring the clinical characteristics,treatment strategy and prognosis of malignant tumor complicated with pulmonary embolism,it can provide the basis for clinical prevention and treatment.METHODSPatients with malignant tumor complicated with pulmonary embolism from Sichuan Provincial People’s Hospital and West China Hospital of Sichuan University from January1,2017 to December 31,2021 were retrospectively collected.Gender,age,BMI,tumor type,comorbidity,time from thrombus to tumor,risk stratification,serological markers,treatment regimen,recurrence of VTE within 1 year,and death were collected.Comparison of the clinical characteristics,complications,laboratory results,treatment strategies,and outcomes within 1 year after discharge in patients with different types of malignant tumors complicated with PE,and in patients who died and did not die.Potential risk factors and independent risk factors were analyzed by univariate Logistic regression and binary Logistic regression.Kaplan-Meier curve was used to analyze the cumulative mortality within 1 year after discharge of different types of tumors with PE in four groups.RESULTS1.A total of 155 patients with PE were included in this study,with an average age of65 years,65 patients with digestive system malignancies,61 patients with lung cancer,10 patients with hematological system malignancies and gynecological malignancies;Within 1 year after discharge,9 cases had recurrent VTE and 57 cases died.2.The surgical operation rate in the death group was lower than that in the non-death group,with a median D-dimer value of 16.2 mg/L in the death group and 6.3mg/L in the non-death group.The median values of CEA,CA125,CA153 and NSE in the death group were higher than those in the non-death group.Death was positively correlated with WBC,LDH,D-D,CEA,CA125,CA153 and NSE,and negatively correlated with Hgb and surgery.3.WBC,D-D,CA153 and NSE were all risk factors for death,P<0.05.CONCLUSIONS1.WBC,HGB,D-D,CA153 and NSE are potential risk factors for death in patients with malignant tumors complicated with PE,while surgery is an protective factor for patients with malignant tumors complicated with PE.2.The gynecological tumor group had the highest a year cumulative survival rate,while the lung cancer group had the lowest a year cumulative survival rate.