Associations Of Serum Lipid Level With Resectable Gastric Cancer Pathological Characteristics And Prognosis

Objective:To explore the correlation between preoperative lipid level and the pathological characteristics of resectable gastric cancer patients,and to analyze the predictive value of blood lipid level in patients with resectable gastric cancer.Methods : The clinical data of 404 patients who underwent radical gastric resection in the First Hospital of Lanzhou University from June 2019 to November 2021 were retrospectively analyzed.The patient’s clinical data is collected through the electronic medical record system,according to total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C),apolipoprotein AI(Apo AI),apolipoprotein B(Apo B)and lipoprotein(a)(LP(a))and other indexes to calculate lipid-related derivative indicators,including Arteriosclerosis Index(AI),Triglycerides to high-density lipoprotein cholesterol ratio(THR),low-density lipoprotein cholesterol to high-density lipoprotein cholesterol concentration ratio(LHR),total cholesterol to high-density lipoprotein cholesterol(TC/HDL-C),Apolipoprotein B to Apolipoprotein AI ratio(Apo B/Apo AI)and triglyceride glucose index(Ty G).The best cut-off value of blood lipid indexes related to overall survival was determined by X-tile software,SPSS 26.0 software was used to analyze the data,logistic regression analysis was used to explore the correlation between preoperative blood lipid level and different clinicopathological features,and the influence of blood lipid level on overall survival(OS)was analyzed by COX regression model.P<0.05 is statistically significant.Results:1.The preoperative TG level and Ty G index were negatively correlated with the p TNM stage in patients with resectable gastric cancer,and the preoperative serum TG level and Ty G index were lower in patients with advanced p TNM stage;the preoperative HDL-C level was negatively correlated with lymphatic vessel invasion Related,the serum HDL-C level was lower in patients with lymphatic vessel invasion;the preoperative LHR value was positively correlated with lymphatic vessel invasion and vascular invasion,and the preoperative LHR value was higher in patients with lymphatic vessel invasion and vascular invasion;2.Kaplan-Meier survival analysis showed: p TNM stage,signet ring cell carcinoma,vascular invasion,preoperative TG,LP(a)level,Ty G index,postoperative Apo AⅠ,Apo B level,AI,THR,LHR,TC/HDL-C values were significantly correlated with OS in patients with resectable gastric cancer.Lower preoperative TG,LP(a)level,Ty G index and lower postoperative Apo AⅠ and Apo B levels are associated with poor prognosis in patients with resectable gastric cancer;higher postoperative AI,THR,LHR,TC/HDL-C values are also associated with poor prognosis relevant.3.COX proportional hazards regression analysis found that preoperative lower LP(a)level,Ty G index and higher AI value were independent risk factors for the prognosis of patients with resectable gastric cancer.Conclusion:1.The preoperative TG level and Ty G index were negatively correlated with the p TNM stage in patients with resectable gastric cancer,and the preoperative serum TG level and Ty G index were lower in patients with advanced p TNM stage;the preoperative HDL-C level was negatively correlated with lymphatic vessel invasion Related,the serum HDL-C level was lower in patients with lymphatic vessel invasion;the preoperative LHR value was positively correlated with lymphatic vessel invasion and vascular invasion,and the preoperative LHR value was higher in patients with lymphatic vessel invasion and vascular invasion;2.Lower preoperative LP(a)level,Ty G index and higher AI value are independent risk factors for the prognosis of patients with resectable gastric cancer.