Analysis Of Constitution And Syndrome Types Of Retinitis Pigmentosa And Analysis Of Drug Use Rules Of Professor Sun He In The Treatment Of Retinitis Pigmentosa Based On Data Mining

Objective:Investigating the characteristics of constitution and syndrome types of retinitis pigmentosa through epidemiology,analyzing the internal relationship between constitution,syndrome types,and retinitis pigmentosa,providing a basis for clinical treatment based on syndrome differentiation and industry standardization,and analyzing Professor Sun He’s medication rules for treating retinitis pigmentosa based on data mining,mining the mentor’s experience and ideas for treating RP,with a view to giving full play to the greatest advantages of traditional Chinese medicine in terms of constitution and empirical medication.Methods:Review the RP patients who visited the ophthalmology department of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine from January 2016 to September 2020,and collect the RP patients who visited the ophthalmology department of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine from September 2020 to January 2023.Collect the general information of the patients(including gender,age,family history,urban and rural distribution,eye type),visual acuity(best corrected visual acuity),TCM physique,and TCM syndrome types,SPSS26.0 was used for data statistical analysis.Collect the traditional Chinese medicine prescriptions of RP patients who were treated by Professor Sun He in the ophthalmology department of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine from January 2016 to January 2023,enter the drug composition of the traditional Chinese medicine prescriptions into an Excel table,establish a database,and conduct frequency analysis,association analysis,cluster analysis,and complex network analysis.Results:1.The frequency of TCM constitution occurrence in patients with retinitis pigmentosa is as follows:peace quality(23%),yang deficiency quality(26%),qi deficiency quality(12%),yin deficiency quality(10%),damp-heat quality(8%),phlegm dampness quality(7%),and blood stasis quality(3%).2.Most of the patients with retinitis pigmentosa have bilateral diseases,the population type is mainly young and middle-aged,most of them do not have family history,and the patients are mostly distributed in cities,with no significant difference in gender distribution.3.The frequency of TCM syndrome types in patients with retinitis pigmentosa:spleen and kidney yang deficiency syndrome(32%),spleen deficiency and qi deficiency syndrome(31%),liver and kidney yin deficiency syndrome(2 5%),and qi deficiency and blood stasis syndrome(12%).4.There was no significant difference in the constitution of retinitis pigmentosa in terms of gender,age,family history,and visual acuity,and there was no statistical significance between residence and visual acuity.5.The correlation analysis between TCM constitution and TCM syndrome types of retinitis pigmentosa showed statistical significance(P<0.05).There was a convergence between the constitution and syndrome types of retinitis pigmentosa patients.6.Ranking of four drugs for the treatment of retinitis pig mentosa:flat>warm>slightly cold>cold>slightly warm>cool>ho t>intense heat;Ranking of five flavors:sweet>pungent>bitter>sour>salty>astringent;Ranking of meridians:kidney meridian>spleen meridian>liver meridian.7.The frequency of use of drugs for the treatment of ret initis pigmentosa is 2176 times,with the frequency ranking as follows:Pori a cocos>wolfberry fruit>licorice>chrysanthemum>yam>tulip>bupleurum>turmeric>astragalus>cornus officinalis.8.Classification of high-frequency traditional Chinese me dicines:tonifying drugs(29.73%),promoting blood circulation and resolving stasis drugs(13.51%),relieving superficies drug s(1 0.8 1%),clearing heat drugs(10.81%),astringent drugs(8.11%),regulating qi drugs(5.4 1%),calming nerves drugs(5.41%),dissipating dampness drugs(5.41%),resolving phlegm,re lieving cough,and asthma drugs(5.4 1%),diuretic and osmolyt ic drugs(2.70%),and hemostatic drugs(2.70%).9.Cluster analysis obtained four types of prescriptions,i ncluding Class Ⅰ prescriptions:raspberry,cistanche,cornus off icinali s,peony bark,yam,turmeric,wolfberry fruit,and chrys anthemum;Class Ⅱ prescription:tangerine peel,mulberry bark,agrimony,safflower,schisandra chinensis;Class Ⅲ prescripti on:Angelica sinensis,Corydalis yanhusuo,Atractylodes lanceo lata,Radix Rehmanniae Preparata;Class V prescription:Codon op si s pilosula,Atractylodes macrocephal a,Amomum villosum,Radix Rehmanniae,Radix Angelicae dahuricae,Semen Ziziphi spinosae,Radix Aconiti,Rhizoma Chuanxiong,Radix Astragali,Curcuma,Radix Bupleuri,Gly cy rrhizae,Pori a cocos.Conclusion:1.Patients with retinitis pigmentosa have a biased physiq ue dominated by yang deficiency.2.The traditional Chinese medicine syndrome types of pa tients with retinitis pigmentosa are mainly spleen and kidney yang deficiency syndrome and spleen deficiency qi deficiency syndrome.3.There is a convergence between traditional Chinese me dicine constitution types and traditional Chinese medicine syn drome types in patients with retinitis pigmentosa.4."The four qi components of therapeuticdrugs are mainly calm and warm,while the five flavors are sweet,spicy,and bitter."The main meridians are the kidney meridian,spleen me ridian,and heart meridian;There are 37 traditional Chinese m edicines(high-frequency traditional Chinese medicine)that ha ve been used≥20 times;The top three high-frequency traditi onal Chinese medicine categories are:tonifying deficiency dru gs,promoting blood circulation and resolving stasis drugs,an d relieving superficies drugs;High frequency Chinese medicin e association analysis:a total of 38 drug pairs were obtained;High frequency cluster analysis of traditional Chinese medici ne:4 types of prescriptions and drug pairs were obtained.