| Obj ective:1.Using data mining methods,summarize the clinical experience of Professor Suqing Yang,our mentor,in treating palmoplantar pustulosis,analyze its medication patterns,and extract core prescriptions to provide reference and basis for clinical diagnosis and treatment of traditional Chinese medicine.2.By using a self control method,observe the clinical efficacy of the mentor’s application of the empirical formula Yiling Dehumidification Decoction combined with the external application of Eight Treasures and Five Gallbladder Medicine Ink in thetreatment of dampness accumulation type palmoplantar pustulosis.Methods:1.Collect 264 cases of patients with palmoplantar pustulosis treated by mentors from September 2018 to September 2021,standardize the case information,enter it into Microsoft Office Excel 2016 to establish a database,and use the software Microsoft Office Excel 2016 to analyze the frequency of general data and drugs;Use software IBM SPSS Modeler 18.0 and IBM SPSS Statistics 23.0 to perform association rule analysis and systematic clustering analysis on high-frequency drugs.2.From December 2021 to December 2022,80 patients with palmoplantar pustulosis of dampness toxin accumulation type who were treated in the dermatology of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine were selected to take Yiling Chushi Decoction orally,and the skin lesions were treated with eight treasures and five bile drugs for 56 days.On the 0 ± 2 days,14 ± 2 days,28 ± 2 days,42 ± 2days,and 56 ± 2 days of treatment,the patient’s PPPASI score and traditional Chinese medicine pruritus syndrome score were observed and recorded.On the 56 ± 2 days,evaluate the clinical efficacy of the patient before and after treatment based on the efficacy index.Results:1.Among the 264 cases,in terms of general data analysis,there were 178 females and 86 males,with a concentrated age range of 4060 years old.2.In terms of prescription and medication,176 types of traditional Chinese medicine were used,resulting in 26 highfrequency drugs and 18 types of drugs.The drug properties were mainly cold and warm drugs,followed by mild drugs.The taste of the drugs was mainly bitter and sweet,followed by spicy drugs.The drug meridians were mostly lung and liver meridians,followed by stomach and kidney meridians.3.Based on association rule analysis,a total of 13 4 core drug combinations were obtained.Combined with network analysis,the core prescriptions for the treatment of palmoplantar pustulosis by the mentor were Tufu Ling,Baiying,Smilax China,Sophora japonica,Centipede,Fangfeng,and Licorice.4.Based on cluster analysis,six high-frequency drug combinations were obtained,including "Smilax China,White English,Dandelion,Artemisia scoparia,Sophora j aponica,and Poria cocos".5.Clinical research results showed that there was a statistically significant difference in PPPASI score and traditional Chinese medicine pruritus syndrome score between patients after treatment and before treatment(P<0.05),with a total effective rate of 84.48%.Conclusions:1.The mentor starts with the treatment of palmoplantar pustulosis from the perspective of toxin and stasis.She believes that this disease is mostly caused by deficiency of the root and deficiency of the spleen,and deficiency of the spleen,and stagnation of dampness,toxin,and stasis.At the same time,it causes dysfunction of qi and blood.She often uses heat clearing anddetoxifying drugs,diuretic and dampness penetrating drugs,and the core prescription is Tu Fu Ling,Bai Ying,Smilax China,Sophora japonica,centipede,Fangfeng,and licorice.2 The combination of Yiling Dehumidifying Decoction and Eight Treasures and Five Gallbladder Medicinal Ink for external use in the treatment of dampness accumulation type palmoplantar pustulosis can effectively improve the patient’s PPPASI score and traditional Chinese medicine pruritus syndrome score,and is a safe and effective treatment plan. |
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