Ankylosing Spondylitis In Remission Merdian-muscle Syndrome Differentiation Characteristics Clinical Research

Objective:To summarize the characteristics and patterns of distribution of transverse tendon foci in patients with ankylosing spondylitis in remission through the study of the nodal tendon lesion points.To observe the clinical efficacy of long circular acupuncture therapy on transverse tendon lesions in ankylosing spondylitis in remission,and to provide new ideas for the clinical treatment of improving sensory and motor dysfunction in patients with ankylosing spondylitis in remission.Methods:1.Study 1: 120 patients with ankylosing spondylitis in remission who met the inclusion criteria were collected.The six meridian and tendons circulating in the neck,chest and back and lumbosacral region of the patients were examined for meridian-sinew lesion points.According to the frequency distribution table of meridian-sinew lesion points,the meridian-sinew syndrome differentiation of the patients was performed to analyze the distribution rule of meridian-sinew syndrome types in remission of ankylosing spondylitis.2.Study 2: 60 patients with the most common single Foot-Taiyang meridian-sinew syndrome were randomly divided into treatment group(n =32)and control group(n = 31).The control group was subcutaneously injected with ecombinant human tumor necrosis factor receptor-Fc fusion protein for injection,25 mg once a week;the treatment group was treated with long circular acupuncture on the basis of the control group,once a week;both groups were treated for 4 courses,lasting for 4 weeks.The changes of spinal mobility,VAS pain score,BASDAI score,BASFI score,laboratory parameters(ESR,CRP),TCM syndrome score and ASAS20 compliance rate before and after treatment were recorded and statistically analyzed using SPSS 26.0.Results:1.Study 1: In this study,the most common meridian-sinew syndrome in remission of ankylosing spondylitis was Foot-Taiyang meridian-sinew syndrome,63 cases were single Foot-Taiyang meridian-sinew syndrome,accounting for 52.50% of all meridian-sinew types,combined meridian-sinew syndrome,and Foot-Taiyang meridian-sinew lesions accounted for 92.50%.There were 9 cases(7.50%)of single Foot-Shaoyang meridian-sinew syndrome,which accounted for 40.83% of compound meridian-sinew syndrome,which was similar to the frequency of Foot-Taiyang meridian-sinew syndrome in compound meridian-sinew syndrome.The remaining four meridians,the Foot-Yangming meridian tendon and Hand-Sanyang meridian tendon only appeared in compound meridian-sinew syndrome.2.Study 2:2.1 Spinal range of motion: the spinal range of motion(occipital-wall distance,finger-to-ground distance,thoracic expansion,Schober test)improved in both groups after treatment,with the treatment group outperforming the control group(P < 0.05).2.2 Main symptom score: the VAS pain score,BASDAI score,and BASFI score in both groups were lower after treatment than before,and the treatment group was better than the control group(P < 0.05).2.3 Laboratory parameters: the laboratory indexes(ESR,CRP)of both groups did not improve significantly after treatment,and the difference between the treatment and control groups was not statistically significant(P > 0.05).2.4 TCM syndrome score: the TCM evidence scores decreased in both groups after treatment,and the treatment group was better than the control group(P < 0.05).2.5 The effective rate of TCM efficacy was 90.00% in the treatment group and 76.67% in the control group,which was higher in the treatment group than in the control group,and the difference was statistically significant(P< 0.05).2.6 ASAS20 attainment rate: 80.00% in the treatment group and 50.00% in the control group.The difference was statistically significant(P < 0.05)when comparing the ASAS20 attainment rates of the two groups.Conclusions:1.Ankylosing spondylitis patients in remission have a variety of meridian-sinew syndromes,mainly a single Foot-Taiyang meridian-sinew syndrome,compound sinew type is Foot-Taiyang meridian-sinew syndrome based on the second and third meridian tendon type.2.Foot-Taiyang meridian tendinopathy as a feature of meridian tendinopathy in remission from ankylosing spondylitis.3.Long circular acupuncture therapy was superior to the control group in terms of pain,joint stiffness status,and joint motion disorders in patients with ankylosing spondylitis in remission,and no adverse effects were observed in the clinic with a good safety profile.