| Objective:The purpose of this study was to investigate and observe the clinical efficacy of Simultaneous Integrated Boost-Intensity Modulated Radiation Therapy(SIB-IMRT)in the treatment of esophageal squamous carcinoma and the factors affecting the prognosis.Methods:The clinical and follow-up data of 220 patients with esophageal squamous carcinoma admitted to the First Affiliated Hospital of Bengbu Medical College from January 1,2017 to December 31,2018 were retrospectively analyzed to assess relevant prognostic factors and analyze their effects on the 5-year overall survival(OS)and 5-year progression-free survival(PFS)of all patients,and the prognostic influencing factors were analyzed by Logrank test and Cox multi-factor regression analysis Results:The median follow-up for the entire group was 65.0 months(3.0-72.0 months),with overall survival rates of 70.0%,51.8%,38.6%,and 27.6% at 1,2,3,and 5 years,respectively,and disease-free survival rates of 53.6%,40.5%,29.1%,and 19.0% at 1,2,3,and 5 years,respectively.The median OS was 26.0 months(95% CI: 20.31-31.69months)and the median PFS was 17.0 months(95% CI: 11.19-22.81 months).Univariate analysis showed that gender,N stage,treatment mode,radiotherapy dose,absolute lymphocyte count(ALC)reduction during radiotherapy,and gross tumor volume(GTV)were associated with 5-year OS and 5-year PFS in patients with esophageal cancer(P<0.05).Multifactorial analysis showed that N stage,radiotherapy dose,treatment modality,ALC reduction and GTV were independent prognostic factors affecting 5-year OS(P<0.05);gender,N stage,radiotherapy dose,treatment modality and GTV were independent prognostic factors affecting 5-year PFS(P<0.05).Conclusions: In the era of SIB-IMRT,the main factors affecting the prognosis of patients with esophageal squamous carcinoma treated with radical radiotherapy(chemotherapy)were gender,N stage,treatment modality,radiotherapy dose,ALC reduction during radiotherapy,and GTV. |
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