Association Between Red Blood Cell Distribution Width And Optic Nerve Damage In Primary Glaucoma

Objective: To investigate the association between red blood cell distribution width(RDW)and optic nerve damage in patients with primary glaucoma.Methods:Retrospective case observation studies were used.A total of 187 patients with primary glaucoma who treated in our hospital from January 2018 to December 2021 were collected as the research group,and the primary glaucoma patients were divided into three subgroups of mild,moderate and severe according to the mean visual field defect(MD)value.A total of 187 age-related cataract patients who visited our hospital during the same period were selected as the control group.The sociodemographic information,blood routine data and ophthalmic examination data of the included subjects were collected,and the changes of RDW level in the two groups and the association between RDW and ocular parameters in the primary glaucoma group were analyzed.Results:The mean RDW level in primary glaucoma group(13.21±0.86)was higher than that in the control group(12.95±1.13)and(P<0.05).Moreover,the RDW level in severe group was significantly higher than that in mild group and moderate groups(P<0.001).The Pearson correlation analysis showed that RDW was negatively correlated with RNFLT and VFI(r=-0.302,P<0.001),in the primary glucoma group TS(r=-0.167,P=0.022),T(r=-0.165,P=0.024),TI(r=-0.214,P=0.003),and MD(r=0.297,P<0.001)was positively correlated.There was no correlation between RDW and other ocular parameters(P>0.05).Multiple linear regression analysis of RDW and POAG and PACG related ocular parameters showed that RDW levels were associated with TS(β=-12.417,t=-2.303,95%CI:-23.067～-1.766,P=0.023),T(β=-6.563,t=-2.034,95%CI:-12.936～-0.190,P=0.044),TI(β=-17.670,t=-3.191,95%CI:-28.608～-6.731,P=0.002)the RNFLT of the three directions showed a negative correlation in the PACG group.Conclusion: The RDW level in patients with primary glaucoma is higher than normal,and RDW level is related to the degree of optic nerve damage in this study.It is expected that RDW level can be used as an indicator to evaluate the progression of primary glaucoma.