Analysis Of MOG Antibody Titer And Clinical Manifestations And Prognosis Of MOG Antibody Associated Disorders

Objectives: To analyze the epidemiological characteristics,clinical manifestations,blood and cerebrospinal fluid laboratory tests,and imaging findings of MOG antibody associated disorders at different antibody titers.To explore the relationship between MOG antibody titers and clinical manifestations and disease prognosis of MOG antibody associated disorders.It is helpful to improve the understanding of the pathogenesis,clinical manifestations,and prognosis of MOG antibody associated disorders.Methods:Retrospectively collected 72 patients with MOG antibody associated disorders from the outpatient and inpatient departments of the department of neurology from January 2018 to September 2022.According to the serum MOG antibody titers at the initial visit,they were divided into antibody low titer group,antibody medium titer group and antibody high titer group.Basic information and clinical data were collected from the three groups,including sociodemographic data,precursor history,clinical presentation,serum MOG antibody titers,CSF-related laboratory results,electrophysiological examination,imaging examination,autoimmune marker results,treatment approach,and evaluated EDSS score at initial onset.The postdischarge behavioral period was followed at 6-12 months to assess the prognosis status and presence of recurrence,and to reevaluate the EDSS score at 6 months after the onset.Data analysis and mapping application to SPSS 25 software.Results:1.General data: 72 patients with MOG antibody associated disorders were enrolled in this study.Among them,31 were male and 41 female,with a mean age of onset of 36.29 years.There was no significant gender difference between titers(p> 0.05)and the age of MOG antibody associated disorders between titers(p> 0.05).2.Course of first onset: The mean course of first onset in 72 patients was 32.84 days,with a median time of 15 days,and there was no significant difference in first onset between groups with different antibody titers(p> 0.05).3.Clinical characteristics:(1)precursor history: 15 patients had precursor history before the onset,and there was no significant difference between different antibody titers(p>0.05).(2)Initial symptoms: the proportion of different antibody titers,and there was no significant difference between different antibody titers(p> 0.05).(3)Clinical phenotype:Statistical clinical phenotypes with different antibody titers,and no significant differences in clinical phenotypes between different antibody titers groups(p> 0.05).4.Imaging characteristics:(1)Optic MRI,no difference in optic MRI between different antibody titers in this study(p> 0.05)(2)Brain MRI,brain MRI difference was not significant(p> 0.05)(3)Spinal MRI,and different antibody titers showed long segment myelitis(p <0.05).Pairwise comparisons between long segment lesions showed significant differences between the high and low titer groups(p <0.05).5.Laboratory examination:(1)Serum MOG antibody: All 72 patients in this study were positive for serum MOG antibody,30(41.7%)in the low titer group of MOG antibody,21(29.2%)in the MOG antibody titer group,and 21(29.2%)in the high titer group of MOG antibody group.(2)In this study,56 patients had completed related autoimmune marker tests.The b sequsequence and thyroiditis antibodies between different antibody titers(p <0.05).For pairwise comparisons between different antibody titers of thyroiditis antibodies,the difference between the high and medium titers groups was significant(p<0.05).In the pairwise comparison of different antibody titers with abnormal rheumatic antibody sequence,the difference between antibody high titer and antibody low titer groups was statistically significant(p <0.05).6.CSF examination: There was no significant difference in CSF abnormalities between the different antibody titers groups in this study(p> 0.05).7.Neuroelectrophysiological examination: There was no significant difference in neuroelectrophysiological examination abnormalities between different antibody titers in this study(p> 0.05).8.EDSS score at the initial disease onset: All the patients included in this study were evaluated for their EDSS score after admission for the first disease onset.Found a significant difference in EDSS scores at the first onset of the three different antibody titers(p <0.05).EDSS scores were significant after pairwise comparisons(p <0.05).The EDSS score at initial onset was positively correlated with serum MOG antibody titer,with correlation coefficient R=0.800 and strong correlation,p <0.01.9.Prognosis:(1)EDSS score 6 months after onset: All patients in this study were reevaluated for EDSS score 6 months after onset to evaluate the prognosis of the patients.Found a statistically significant difference in patient outcome EDSS scores between the three different antibody titer groups(p <0.05).Statistical p <0.05 after pairwise comparisons.Prognostic EDSS score was positively correlated with MOG antibody titer,correlation coefficient R=0.594,p <0.01.(2)A total of 19 patients had recurrent events in this study,and different antibody titers(p <0.05).After pairwise comparisons,the difference between the high and medium titers and low titer groups was statistically significant(p <0.05).Conclusion: 1.When MOG antibody associated disorders involve the spinal cord,patients with high MOG antibody titers were more likely to present with long-segment myelitis than those with low MOG antibody titers.2.Patients with medium and high antibody titers in MOG antibody associated disorders are more likely to associate with abnormal rheumatic antibody series and abnormal thyroiditis antibody than patients with low antibody titers.3.Patients with higher MOG antibody titers for the first onset,the more severe their clinical manifestations,and the higher the EDSS score for the initial onset.EDSS score scores were positively correlated with first onset serum MOG antibody titers.4.Patients with higher MOG antibody titers had worse prognosis and higher prognosis EDSS score.The prognostic EDSS score was positively correlated with the first-onset serum MOG antibody titers.5.Patients with medium and high antibody titers in the first onset of MOG antibody associated disorders had a higher probability of recurrence than those with low antibody titers.