Cross-sectional Study On The Association Between Serum Uric Acid And Sarcopenia

Objective: As a progressive and systemic skeletal muscle disease,sarcopenia is commonly seen in the elderly population and seriously affects their health and quality of life.However,sarcopenia may have adverse effects in younger age groups due to various factors such as malnutrition and reduced physical activity.Serum uric acid(SUA)is the end product of purine metabolism in the human body.There are limited and controversial studies on the association between SUA and sarcopenia.In this study,we conducted a cross-sectional survey in a northeastern population with the aim of exploring the association between SUA and sarcopenia as well as its components.Methods: Based on hanman community cohort study,a cross-sectional survey was carried out from July 2018 to June 2020 in Shenyang and Fushun.General demographic characteristics,dietary history,personal habits,physical activity level,disease history,physical examination indexes,and blood test results were collected through face-to-face questionnaires,physical examination,and hematological tests.The subjects were divided into three groups: no sarcopenia,possible sarcopenia,and sarcopenia according to the 2019 Asian Working Group on Sarcopenia diagnostic criteria.The subjects were classed into three groups according to tertiles of SUA.If the continuous variables met the KolmogorovSmirnov normality test,analysis of variance was used for comparison between groups;if the continuous variables between groups did not meet Kolmogorov-Smirnov normality test,Kruskal-Wallis was used for comparison.Categorical variables were compared using the Chi-square test.Taking age,sex,ethnicity,BMI,education,annual household income,smoking status,alcohol consumption,physical activity,e GFR,chronic disease,total energy intake,and protein intake as covariates,multivariate adjusted logistic regression was used to analyze the association between SUA and sarcopenia as well as reduced muscle mass,grip strength,and gait speed using the lowest SUA quartile as a reference.Subgroup analysis and multiplicative interaction were conducted according to age(<60 vs.≥60 years),sex(female vs.male),and chronic disease status(no vs.yes).The association between SUA and muscle mass,grip strength,and gait speed was also assessed by multiple linear regression.Sensitivity analysis was conducted in subjects with normal renal function and without hyperuricemia,respectively,to explore the association between SUA and sarcopenia and its components at different periods.Results: Among 4269 subjects in this study,the prevalence and 95% confidence interval(CI)of possible sarcopenia was 10.61%(9.72%,11.57%)and the prevalence and 95% CI of sarcopenia was 3.12%(2.64%,3.69%)among 4269 subjects.Multivariate adjusted logistic regression analysis showed no statistical association between SUA and possible sarcopenia as well as sarcopenia,with odds ratio(OR)and 95% CI of 1.08(0.81,1.43)and1.22(0.71,2.09),respectively.In the analysis of the association between SUA and the components of sarcopenia,the highest SUA tertile was negatively associated with reduced muscle mass compared with the lowest SUA tertile,with an OR and 95% CI of 0.53(0.35,0.81),and subgroup analyses showed that in women and those under 60 years of age,the highest tertile had a reduced risk of reduced muscle mass compared with the lowest SUA tertile,with an OR and 95% CI 0.55(0.33,0.91)and 0.47(0.27,0.81),respectively.In the total population and different subgroups,no association between SUA and reduced grip strength and gait speed was found.Multiple linear regression showed a positive association between SUA and muscle mass as well as grip strength,with regression coefficients β and95% CI of 0.00036(0.00025,0.00047)and 0.00336(0.00047,0.00625),respectively,and no linear association between SUA and gait speed was observed.The results of sensitivity analysis in patients with normal renal function and without hyperuricemia were consistent with those of the main analysis.Conclusions: There was no statistical association between SUA and possible sarcopenia,sarcopenia,or gait speed.SUA was negatively correlated with reduced muscle mass and SUA was positively correlated with muscle mass and grip strength levels.