Research Of The Correlation Between TCM Syndrome Types And Arterial Blood Gas Of Acute Exacerbation Of Chronic Obstructive Pulmonary Disease

Objective:Through the study of the correlation between different TCM syndromes and arterial blood gas in patients with AECOPD,to explore the relationship between various TCM syndromes and arterial blood gas indicators,to further enrich the TCM syndrome differentiation methods,to provide a scientific basis for TCM diagnosis and treatment of diseases in western medicine,and to guide the clinical application of integrated traditional Chinese and western medicine theory to more accurately diagnose and treat this disease.Methods:We collected the general data and TCM symptom questionnaire of the 150 patients meeting the inclusion criteria,conduct TCM syndrome differentiation and classification,sorted out their arterial blood gas values。Statistical analysis of variance and rank sum test were used to analyze the correlation of various TCM syndrome and arterial blood gas indexes.Results:1.The effective samples were 150 cases,129 male cases and 21 female cases;the average age was 68.34 ± 4.74 years.Among 150 samples,19 cases were syndrome of spirit-orifices confused by phlegm,20 cases were syndrome of wing-cold attacking lung,23 cases were syndrome of external cold internal drink,43 cases were syndrome of phlegm-damp in the lung,45 cases were syndrome of phlegm-heat in the lung,.2.There was no difference in the level of PH(P>0.05)in different syndromes of AECOPD.3.Pa O2 values in different syndromes of AECOPD were significantly different at(P=0<0.05).The level of arterial partial pressure of oxygen gradually decreased,from syndrome of wing-cold attacking lung,syndrome of external cold internal drink,syndrome of phlegm-damp in the lung,syndrome of phlegm-heat in the lung,syndrome of spirit-orifices confused by phlegm.After further multiple comparison,the difference was significant in statistic(P<0.05): Pa O2 of syndrome of spirit-orifices confused by phlegm was higher than the other four syndrome types.There was no difference in the level of Pa O2 between the syndrome of phlegm-damp in the lung and syndrome of phlegm-heat in the lung.But Pa O2 of syndrome of phlegm-heat in the lung was lower than the syndrome of wing-cold attacking lung and syndrome of external cold internal drink.Pa O2 of syndrome of phlegm-damp in the lung was lower than the syndrome of wing-cold attacking lung and syndrome of external cold internal drink.There was no difference in the level of Pa O2 between the syndrome of wing-cold attacking lung and syndrome of external cold internal drink.4.Pa CO2 values in different syndromes of AECOPD were significantly different at(P=0<0.05).The level of Pa CO2 gradually increased,from wing-cold attacking lung,external cold internal drink,phlegm-damp in the lung,phlegm-heat in the lung,spirit-orifices confused by phlegm.After further multiple comparison,the difference was significant in statistic(P<0.05): Pa CO2 of syndrome of wing-cold attacking lung was lower than the other four syndrome types.There was no difference in the level of Pa CO2 between the syndrome of wing-cold attacking lung and syndrome of external cold internal drink.Pa CO2 of syndrome of external cold internal drink was lower than the syndrome of phlegm-damp in the lung,syndrome of phlegm-heat in the lung and syndrome of spirit-orifices confused by phlegm.Pa CO2 of syndrome of phlegm-damp in the lung was lower than the syndrome of phlegm-heat in the lung and syndrome of spirit-orifices confused by phlegm.There was no difference in the level of Pa O2 between the syndrome of phlegm-heat in the lung and syndrome of spirit-orifices confused by phlegm.5.OI values in different syndromes of AECOPD were significantly different at (P=0<0.05).The level of OI gradually decreased,from syndrome of wing-cold attacking lung,syndrome of external cold internal drink,syndrome of phlegm-damp in the lung,syndrome of phlegm-heat in the lung,syndrome of spirit-orifices confused by phlegm.After further multiple comparison,the difference was significant in statistic(P<0.05): OI of syndrome of spirit-orifices confused by phlegm was higher than the other four syndrome types.There was no difference in the level of OI between the syndrome of phlegm-damp in the lung and syndrome of phlegm-heat in the lung.But OI of syndrome of phlegm-heat in the lung was lower than the syndrome of wing-cold attacking lung and syndrome of external cold internal drink.OI of syndrome of phlegm-damp in the lung was lower than the syndrome of wing-cold attacking lung and syndrome of external cold internal drink.There was no difference in the level of OI between the syndrome of wing-cold attacking lung and syndrome of external cold internal drink.6.Among the five syndromes of AECOPD,patients had the most type II respiratory failure,followed by patients without respiratory failure,and fewer patients had type I respiratory failure.Patients of the syndrome of wing-cold attacking lung and syndrome of external cold internal drink were without respiratory failure.Patients of the syndrome of phlegm-damp in the lung was with type I respiratory failure.Patients of the syndrome of phlegm-heat in the lung and syndrome of spirit-orifices confused by phlegm were with type II respiratory failure,all patients of the syndrome of spirit-orifices confused by phlegm was with type II respiratory failure.Conclusion:1.TCM syndrome types of AECOPD are correlated with Pa O2、Pa CO2、OI.The specific manifestations are as follows: The level of Pa O2 and OI gradually decreased,from syndrome of wing-cold attacking lung,syndrome of external cold internal drink,syndrome of phlegm-damp in the lung,syndrome of phlegm-heat in the lung,syndrome of spirit-orifices confused by phlegm.Corresponding to a gradual increase in Pa CO2.2.Among the five syndrome types of AECOPD,the most patients had type II respiratory failure,followed by patients had type I respiratory failure,and fewer patients without respiratory failure.Patients of the syndrome of wing-cold attacking lung and syndrome of external cold internal drink were without respiratory failure.Patients of the syndrome of phlegm-damp in the lung was with type I respiratory failure.Patients of the syndrome of phlegm-heat in the lung and syndrome of spirit-orifices confused by phlegm were with type II respiratory failure,all patients of the syndrome of spirit-orifices confused by phlegm was with type II respiratory failure.