| Objective: To observe the clinical efficacy of Mailuoshutong pills in preventing EHIT after radiofrequency ablation for varicose veins of lower extremity,and to provide basis for clinical guidance in preventing venous thrombosis of lower extremity veins after radiofrequency ablation.Methods: A total of 92 patients with varicose great saphenous vein admitted to the First Department of General Surgery of Yunnan First People’s Hospital from October 2021 to December 2022 were collected.All patients were treated with radiofrequency ablation of the main saphenous vein.Randomized number table method was used to divide 31 cases into control group,no postoperative anticoagulation treatment;In the Chinese patent medicine treatment group,30 cases were treated with "Mailuoshutong pills";Thirty-one patients in the western medicine treatment group were treated with "rivaroxaban" anticoagulant therapy,and the changes of lower limb vascular ultrasound and VCSS score were observed and compared in each group before and after surgery,so as to know the incidence of postoperative EHIT and evaluate the clinical efficacy of drugs.Result:1.Compared with the control group,there was a significant reduction in the incidence of EHIT in both treatment groups(p<0.05),indicating that both Mailuoshutong pills and Rivaroxaban can reduce the incidence of EHIT after radiofrequency ablation of lower varices.There was no statistical significance in the incidence of EHIT between the two treatments(p>0.05).2.The VCSS score and CEAP grade were significantly lower in all three groups 2 days after surgery and 1 month after surgery compared with those before surgery,indicating good treatment effects in all three groups(p<0.05).Comparison between the two groups showed that VCSS score and CEAP grade at 1 month after surgery were lower in both treatment groups compared with the control group(p<0.05).Both Mauloshutong pills and Rivaroxaban could effectively improve the clinical venous severity of patients after surgery.3.Traditional Chinese Medicine syndrome scores of patients in the three groups were significantly decreased 1 month after surgery compared with those before surgery and 2 days after surgery(p<0.001).Comparison between the two groups showed that the TCM syndrome scores of the control group and the Rivaroxaban group did not significantly decrease before surgery compared with 2 days after surgery(p>0.05).However,the TCM syndrome score of Mailuoshutong pills group was lower at 2 days after surgery than before surgery(p<0.001).4.Comparison of TCM syndrome pain scores of 3 groups at 2 days after surgery showed that the pain scores in the Mailuoshuitong pills group decreased compared with the control group(p<0.001)and Rivaroxaban group(p<0.001).There were no significant changes between Rivaroxaban group and control group(p>0.05).The score of TCM syndrome pain,in Mailuoshutong pills group was lower in the Mailuoshuitong pills group compared with the control group at 1 month after surgery(p<0.001),and no significant decrease compared with the rivaroxaban group(p>0.05).There was no significant difference in the rivaroxaban group compared with the control group(p>0.05).5.Compared with Rivaroxaban group,the subcutaneous ecchymosis score of TCM syndrome in Mailuoshuitong pills group decreased at 2 days after surgery(p<0.001)and 1 month after surgery(p<0.001).There was no significant difference in the control group compared with the Mailuoshutong pills group and Rivaroxaban group at 2 days after surgery and 1 month after surgery(p>0.05).6.Correlation analysis showed that VCSS score and CEAP grade before surgery were positively correlated with Caprini score,changes in TCM syndrome score(1 month postoperatively versus preoperatively),changes in TCM syndrome pain score(1 month postoperatively versus 2 days postoperatively),and changes in TCM syndrome subcutaneous ecchymosis score(1 month postoperatively versus 2 days postoperatively)(p<0.05).VCSS score before surgery was positively correlated with age(p<0.05).The changes in TCM syndrome subcutaneous ecchymosis score(1 month and 2 days after surgery)was positively correlated with D-dimer(p<0.05).Conclusion: Mailuoshutong pills has a preventive effect on the occurrence of postoperative EHIT and reduces the risk of postoperative bleeding and ecchymosis,and can significantly improve the symptoms of lower limb swelling and pain in patients with varicose veins. |
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