Construction And Electrochemical Performance Research Of Non-enzymatic Glucose Microsensor For Human Health

With the improvement of living standards,the number of diabetics in China has also increased.Common treatments for diabetes include exercise therapy,medical nutrition therapy,and drug therapy.No matter what methods are used to treat diabetes,being able to obtain the glucose concentration in the patient’s body at any time is very beneficial to the control of diabetes.Therefore,how to detect the glucose concentration in diabetics conveniently,quickly and accurately has become an urgent problem in the field of diabetes medicine.According to the requirements of high integration,miniaturization and low detection limit for sensor,a glucose microensor was manufactured by Micro-Electro-Mechanical system in this paper.On the basis of microsensor,this paper constructs glucose electrochemical sensors based on cuprous oxide（Cu₂O/Ag）,nickel cobaltate（Ni Co₂O₄）and cobalt tetroxide/magnesium ferrite（Co₃O₄/Mg Fe₂O₄）nanomaterials to improve the electrochemical properties performance of the glucose sensor,improve its conductivity and promote charge transfer in the electrocatalytic process of glucose,which enhances the response of the metal oxide-based glucose electrochemical sensor and shortens the response time.Firstly,hydrothermal and calcination methods were used to prepare sensitive materials for detecting glucose,and then XPS,SEM,XRD and TEM characterization methods were adopted to determine and analyse element compositions,microstructures,surface morphology,atomic valence of the sensitive materials.The glucose detection system was used to test catalytic performance of the sensors’sensitive material,optimal working voltage of the sensor,and sensitivity,linearity,repeatability,anti-interference ability and long-term stability of the sensor.Then the practicability of the sensor was tested from the perspective of practicability and non-invasiveness.In this paper,human sweat and urine were used as the substrate,and the practicability of the sensor was determined by comparing the detected value of the sensor with the actual glucose concentration contained in the samples.Finally,the mechanism of glucose concentration detection and sensitization mechanism of glucose electrochemical sensor were explained from the perspectives of charge transfer,the synergistic effect between the double metal oxide and the metal oxide,the reaction equation between the sensor’s sensitive material and glucose.Finally,the mechanism of glucose concentration detection by the glucose electrochemical sensor was explained from the perspective of the reaction equation between the sensor’s sensitive material and glucose.The high-performance metal oxide-based glucose electrochemical microsensor was constructed for the detection of glucose in human body in this paper.The electrochemical characteristics of the sensor were detected and the detection mechanisms of the sensor for glucose were revealed.This work had opened up a new field for the metal oxide-based glucose detection.It also provided a certain theoretical guidance for the development of glucose sensors which are used in human body to detect glucose concentration,and had a certain reference effect on the painless detection of glucose concentration in human body,real-time detection and miniaturization of detection devices.