Analysis Of Corneal Biomechanics And Other Ocular Biological Parameters In Adult Myopia

Objective: To study the characteristics of corneal biomechanics and other biological parameters of the eye in adults with different degrees of myopia,and analyze the influencing factors.Methods: Through cross-sectional study,366 adult patients(718 eyes)with different degrees of myopia were selected from October 2021 to November 2021 from the First Affiliated Hospital of Dali University and Dali Ophthalmology and Ophthalmology Hospital,aged 18-50 years old,with sphericity equivalent(SE)of-0.50 D to-16.75 D.The axial length(AL)was measured with optical biometer,the mean keratometer data(Km)and anterior chamber depth(ACD)of other biological parameters of the eye were measured with Pentacam,and the corneal biomechanical parameter,central corneal thickness(CCT)and biomechanical corrected intraocular pressure(b IOP)were measured with Corvis ST.The subjects were divided into low myopia,moderate myopia and high myopia groups according to SE.The overall difference between the groups was compared by one-way ANOVA,and the further pairwise comparison between the groups was performed by LSD-t test.Pearson correlation analysis was used to analyze the correlation between the two variables.Results: 1.There were statistically significant in age,SE,AL,ACD among groups(P < 0.001),but no statistically significant in gender,Km,CCT,IOP(P > 0.05).2.Comparison of corneal biomechanical parameters among groups: A2L(P=0.017),A2T(P=0.008),A2V(P < 0.001),PD(P < 0.001),HCR(P=0.049),DA(P < 0.001),ARTh(P< 0.001),SSI(P < 0.001)had statistically significant,while the remaining parameters were not statistically significant(P > 0.05).3.Through the correlation analysis of the factors that may affect the corneal biomechanics,it was found that SE,AL,Km,ACD,IOP,CCT,and age had different degrees of influence on the corneal biomechanical parameters.The correlation analysis of PD and SE,AL showed that PD was negatively correlated with SE(r=-0.216,P<0.001),and PD was positively correlated with AL(r=0.358,P<0.001).The correlation analysis of SSI and SE,AL showed that SSI was positively correlated with SE(r=0.361,P < 0.001),and SSI was negatively correlated with AL(r=-0.331,P < 0.001).4.The correlation between SSI and other corneal biomechanics,IOP,CCT and age was analyzed.Except that ARTh(P=0.742),TBI(P=0.664),CBI(P=0.253)were not correlated with SSI,other parameters had different degrees of correlation with SSI.Among them,SSI was significantly correlated with A2 V,PD,HCR,DA,IR,and SSI was significantly positively correlated with A2V(r=0.546,P< 0.001)and HCR(r=0.408,P < 0.001),SSI was negatively correlated with PD(r=-0.473,P < 0.001),DA(r=-0.557,P < 0.001)and IR(r=-0.545,P < 0.001).Conclusion: 1.With the increase of myopia degree and axial length,the cornea is more prone to deformation.A2 V,PD,DA,and SSI may be valuable corneal biomechanical indicators for predicting adult myopia research.2.SSI index decreased more significantly in high myopia,which may provide a new way to study the pathogenesis of myopia.3.Through conducting corneal biomechanical examination on adult myopia,it can be used as a preoperative evaluation for corneal refractive surgery to avoid the occurrence of surgical complications.