Analysis Of Risk Factors Of Venous Thromboembolism In Patients With Lung Cancer

Purpose:This study aims to investigate the incidence of venous thromboembolism(VTE)in lung cancer patients and explore the risk factors affecting its occurrence,in order to provide scientific basis for the prevention of VTE in lung cancer patients.Methods:In this study,258 patients with lung cancer admitted to the Affiliated Hospital of Inner Mongolia Medical University from September 2017 to September 2022 were included in the study through retrospective analysis,and were divided into VTE group and non-VTE group according to whether they had venous thrombosis.All subjects met the inclusion and exclusion criteria,all subjects signed informed consent,and this study was approved by the Ethics Committee of Inner Mongolia Medical University.Demographic data,lifestyle,past medical history,clinical data,laboratory test indicators and other data were collected.SPSS26.0(SPSS Inc.,Chicago,USA)was used for statistical analysis.Univariate and multivariate logistic regression analysis was used to explore the risk factors of lung cancer complicated with venous thrombosis.Results:1.The proportion of patients with a high BMI level,smoking history,alcohol consumption,tuberculosis,COPD,cough,chest pain,and dyspnea in the VTE group was significantly higher than that in the non-VTE group(P<0.05),while there was no significant difference in age and gender between the two groups(P>0.05).2.The proportion of patients with cancer located in the upper lobe of the left lung and the middle lobe of the right lung,squamous cell carcinoma,and tumor stage III/IV was significantly higher in the VTE group than in the non-VTE group(P<0.05).3.The proportion of patients undergoing surgery,targeted therapy,radiation therapy,and two or more treatments was significantly higher in the VTE group than in the non-VTE group(P<0.05),while there was no significant difference between the two groups in terms of chemotherapy and no treatment(P>0.05).4.Multivariate logistic regression analysis showed that squamous cell carcinoma(OR:2.22.95%CI 1.07,9.72),tumor stage III/IV(OR: 3.86.95%CI: 1.50,7.61),and surgery(OR:3.66.95%CI 1.11,10.73)were independent risk factors for VTE in lung cancer patients.Conclusion:1.Lung cancer patients with a high BMI index,smoking and alcohol consumption habits,medical history of COPD and tuberculosis,clinical symptoms of chest pain,cough,sputum,and dyspnea,and history of surgical treatment,biological targeted therapy,and radiation therapy are more prone to develop VTE.2.Tumor stage III/IV,surgery,and squamous cell carcinoma are independent risk factors for VTE in lung cancer patients.