Relationship Between Appendiceal Orifice Inflammation And Prognosis Of Ulcerative Colitis

Objective:To evaluate the effect of endoscopic appendiceal orifice inflammation(AOI)on the prognosis of ulcerative colitis(UC).Methods:Retrospectively collected UC patients who received colonoscopy at the Second Hospital of Shanxi Medical University and Shanxi Cancer Hospital from October 2015 to October 2022,and calculated the cumulative risk of complete ER(endoscopic remission,ER),hospitalization and proximal disease extension using Kaplan-Meier method.Cox proportional model was used to conduct multivariate analysis to study the important risk factors of complete ER.Results:A total of 202 UC patients were included,116 of whom were accompanied by AOI.There was no significant difference in general characteristics except age between AOI group and non-AOI group.The cumulative risk of complete ER was significantly different between AOI group and non-AOI group(P=0.033).There was no significant difference in the cumulative risk of other disease outcomes between the AOI group and the non-AOI group(hospitalization,P=0.958;proximal disease extension,P=0.078).Multivariate Cox regression analysis also showed that AOI was an important risk factor for complete ER in UC patients(HR=0.465,95% CI: 0.221 – 0.979;P=0.044).Conclusion:AOI is significantly associated with lower complete ER rate in UC patients.Therefore,it is recommended to develop more accurate treatment and follow-up plan to help UC patients with AOI achieve complete ER.