Value Of CTP Technique In The Evaluation Of Plantar Soft Tissue Microcirculation Perfusion In Diabetic Foot Patients

Objective:By Computed Tomography Perfusion(CTP)technology,we quantitatively evaluated microcirculation perfusion in the soft tissue surrounding diabetic foot and lower limb,and discussed the application value of CTP technology in the lower limb microcirculation perfusion,and understood the situation of microcirculation perfusion in the soft tissue surrounding diabetic foot patients,and discussed reliability of this technique in microcirculation evaluation.Methods:Twelve patients with diabetic foot were prospectively included,all of whom were unilateral obvious symptoms of diabetic foot,including 9 males and 3 females,aged 45-72 years..GE Revolution 256-slice spiral CT was used to perform perfusion scanning on both feet.The Time-Density Curve(TDC)and related perfusion indexes,including Blood Flow(BF)and Blood Volume(BV),Mean Transit Time(MTT),the passage time to reach the peak of the pulse residual function(Tmax)were compared and analyzed.Results:BF,BV,MTT and Tmax of the affected foot group and control group were(31.54±18.61)vs(14.56±4.18)m L/min,3.37(2.23,5.31)vs 0.49(0.42,1.02)m L,(4.34±1.44)vs(5.86±1.33)s,(4.53±1.71)vs(6.06±1.81)s.After paired T-test and nonparametric rank-sum test,the difference of BF,BV and MTT between the two groups was statistically significant(P<0.05).All patients achieved good agreement among different observers.Conclusion:CT perfusion imaging can quantitatively evaluate the microcirculation blood perfusion in the plantar soft tissue of diabetic foot patients,and the technique is reliable in the evaluation of microcirculation.CT perfusion imaging can help clinical to understand and discover the microcirculation perfusion of lower extremity in different stages of diabetic patients,and it also can provide assistance for the next step of treatment.