Research On The Correlation Between Neutrophil-to-Lymphocyte Ratio,Systemic Immune-Inflammation Index And Blood Pressure Circadian Rhythm In Hypertensive Population

Objective:To investigate the relationship between blood pressure circadian rhythm and neutrophil-to-lymphocyte ratio 、systemic immune-inflammation index in hypertensive population.Methods:A total of 454 patients who met the criteria for hypertension in the Department of Cardiology of Third Hospital of Shanxi Medical University were included in the study,including 243 males and 211 females,and hypertension patients were divided into dipping group(135 cases),non-dipping group(176 cases),and reverse-dipping group(143 cases)according to the rate of nocturnal blood pressure decline.The patient’s general clinical baseline data,24-hour ambulatory blood pressure,echocardiogram indicators and other information were recorded,and the serum neutrophil-to-lymphocyte ratio(NLR)and systemic immune-inflammation index(SII)level at the time of admission were calculated,and the data were compiled and statistically analyzed.Results:1.Through the comparison and correction between groups,it was concluded that compared with the patients in the dipping group,there was a significant difference in SII(P<0.05)in the non-dipping group,and then logistic binary regression analysis was carried out,after balancing the influencing factors such as age,gender,LDL-C and other influencing factors,SII was still an independent risk factor for the rate of nocturnal blood pressure decline in hypertensive patients(the rate of nocturnal blood pressure decline:OR=1.001,95% CI1-1.001,P<0.05);2.The ROC curve analysis of the SII level showed that the critical value of SII was597.39,the AUC was 0.586,the sensitivity was 0.517,the specificity was 0.649,and the Youden index was 0.176;the area under the patient operating characteristics(ROC)curve of patients with non-dipping hypertension was > 0.586,which has some predictive value;However,NLR was not significantly different after comparison and correction between groups.3.Spearman analysis showed that the rate of nocturnal blood pressure decline was significantly negatively correlated with SII [(r=-0.113)(P<0.05)].4.A total of 454 patients in the three groups,including 135 cases in the dipping hypertension group,176 cases in the non-dipping hypertension group,and 143 cases in the reverse dipping hypertension group.After comparison between groups and correction,it was concluded that there was a significant difference in LDL-C in the reverse-dipping group(P<0.05),and LDL-C in the reverse-dipping group was significantly lower than that in the dipping group.5.Compared with the patients in the dipping group,there were significant differences in red blood cell count,hemoglobin and hematocrit in the non-dipping group and the reverse-dipping group(P<0.05),which was statistically significant.The red blood cell count,hemoglobin and hematocrit of patients in the non-dipping group and the reverse-dipping group were significantly lower than those in the dipping group.Conclusions:1.SII is an independent risk factor for patients with non-dipping hypertension and is a related factor for changes in the circadian rhythm of blood pressure.2.SII has a certain predictive ability for the occurrence of non-dipping hypertension patients,and is stronger than NLR;The relationship between NLR and blood pressure circadian rhythm in hypertensive patients still needs further research and verification.3.The rate of nocturnal blood pressure decline is negatively correlated with SII.4.The reversal of the circadian rhythm of blood pressure in hypertensive patients may inhibit the synthesis of LDL-C.5.The disorder of blood pressure circadian rhythm in hypertensive patients may have a destructive effect on red blood cells and hemoglobin while changing hemodynamics.