Correlation Between Triglyceride-glucose (TyG) Index And Lung Ventilation Function In Physical Examination Population In An Enterprise

Objective: The correlation between blood glucose and lipid metabolism and pulmonary ventilation dysfunction in petrochemical workers was analyzed,and the triglyceride-glucose(TyG)index was constructed to discuss its predictive value for pulmonary ventilation dysfunction,and the mechanism of action of blood glucose and lipid metabolism on pulmonary ventilation dysfunction was preliminarily explored,providing theoretical reference for early clinical prevention and control of pulmonary ventilation dysfunction.Methods: The case-control study was used for the Research.The subjects with pulmonary ventilation dysfunction in the physical examination Center of the Fourth Affiliated Hospital of Gansu University of Traditional Chinese Medicine were selected as the case group,and the subjects with normal pulmonary function test results in the same period were selected as the control group.The general demographic characteristics,occupational history and smoking history of the case group and the control group were retrospectively collected.Blood biochemical indexes related to blood glucose and blood lipid were measured,and the expression of serum inflammatory factors was detected by enzyme-linked immunosorbent assay.Univariate analysis was used to analyze the metabolic characteristics of blood glucose,blood lipid,and inflammatory factors between the case group and the control group.Logistic regression model was established to analyze the effects of glucose and lipid metabolism and TyG index on pulmonary ventilation function.Results:(1)Univariate analysis showed that there was no significant difference in the distribution of triglyceride,high density lipoprotein,triglycerid-glucose index between the obstructive pulmonary ventilation dysfunction group and the control group((P>0.05));There were statistical differences in the distribution of total cholesterol,low density lipoprotein,and fasting blood glucose between the two groups(P<0.05);(2)Age stratification analysis showed that there was no significant difference in t he distribution of triglyceride,high-density lipoprotein,fasting blood glucose,and trigl ycerid-glucose index between the obstructive pulmonary ventilation dysfunction group a nd the control group in the group of ≤45 years old(P>0.05);There were significant differences in the distribution of total cholesterol and low density lipoprotein between the two groups(P<0.05);The distribution of blood glucose and blood lipid in the 45 years old group was similar to that in the ≤45 years old group.(3)Multivariate analysis showed that total cholesterol [OR(95%CI):1.83(1.47-2.26)] and low density lipoprotein [OR(95%CI):0.43(0.34-0.57)] were associated with obs-tructive pulmonary ventilation dysfunction,while triglyceride [OR(95%CI):1.06(0.96-1.18)],high-density lipoprotein cholesterol [OR(95% CI):0.83(0.38-1.82)],fasting bloodsugar [OR(95% CI):1.09(0.97-1.23)],triglycerides,and glucose index [OR(95% CI):1.12(0.85-1.46)] was not correlated with obstructive pulmonary ventilation dysfunction.(4)Graded according to the severity of obstructive pulmonary ventilation dysfunction,it was found that triglyceride and high-density lipoprotein were not related to the disease,(P>0.05),while the distribution of total cholesterol,low-density lipoprotein,fasting blood glucose,and triglycerid-glucose index in the moderate to severe obstructive pulmonary ventilation disorder group and the control group were statistically different,(P<0.05).The area under the ROC curve of triglyceride-glucose index for predicting moderate to severe obstructive pulmonary ventilation dysfunction was 0.58,95%CI was 0.50-0.66.(5)Overweight/obesity [OR(95%CI):1.76(1.01-3.07)],dyslipidemia [OR(95%CI):2.83(1.41-5.73)],and high fasting blood glucose [OR(95%CI):1.42(1.14-1.76)] were risk factors for restrictive pulmonary ventilation dysfunction.(6)Multivariate Logistic regression analysis showed that after adjusting blood glucose and blood lipid,there was no correlation between triglyceride-glucose index and restrictive pulmonary ventilation disorder.(7)The concentrations of serum C-reactive protein,interleukin-10,human growth transforming factor-β and resistin in the mixed pulmonary ventilation dysfunction group and the control group were statistically different,(P<0.05).Conclusions:(1)Elevated fasting blood glucose and TyG index are risk factors for moderate to severe obstructive pulmonary ventilation dysfunction.(2)TyG index could not predict the occurrence of moderate to severe obstructive pulmonary ventilation dysfunction.(3)Obesity/overweight,dyslipidemia,and hyperglycemia increase the risk of restrictive pulmonary ventilation dysfunction.(4)Serum C-reactive protein,interleukin-10,human growth transforming factor-β,resistin and other inflammatory factors are related to the occurrence of pulmonary ventilation dysfunction.