The Role Of Lung Function,FeNO,C-ACT,IgE And Eos Monitoring In The Control Of Bronchial Asthma In Children And Their Correlation

Objective: To discuss the role of pulmonary function,Fe NO,C-ACT,Ig E and Eos monitoring in the control of bronchial asthma in children and to make correlation studies to provide a basis for the assessmentof the control level of bronchial asthma and the adjustment of the treatment plan.Methods: Children aged 5-11 years with asthma who attended the respiratory clinic of the Department of Pediatrics at the Second Hospitalof Hebei Medical University from July 2021 to January 2023 were selected as the study population.The information of the children with asthma were collected and collated,and their names,gender,age,height,weight,pulmonary function parameters,Fe NO,total Ig E,C-ACT score,peripheral blood Neu,Eos,Bas absolute values,allergen results were recorded,and the differences in indicators between the two groups were analyzed according to the level of asthma symptom control,and then a correlation study of indicators was made for all the study subjects.Results:1.There was no statistically significant difference in age,sex,height,weight,BMI and atopic body mass between children with asthma in the fully controlled group and those in the not fully controlled group(P>0.05).2.Compared to the the fully controlled group,FEV1% pred,FEV1/FVC%,FVC% pred,PEF% pred,MMEF 75/25% pred,FEF25% pred,FEF50% pred,FEF75% pred and C-ACT scores in the not fully controlled group decreased.The difference was statistically significant(P<0.05).3.There was no significant difference in Fe NO,Ig E,the absolute values of Neu,Eos and Bas between children with asthma in the fully controlled group and those in the not fully controlled group(P>0.05).4.There was a positive correlation between FEF75% pred and Fe NO in children with asthma(P<0.05),while the rest of the lung function indicators did not correlate with Fe NO(P>0.05).5.There was a positive correlation between FEV1% pred,FEV1/FVC%,PEF% pred,FEF25% pred,FEF50% pred,FEF75% pred,MMEF75/25% pred and C-ACT scores in children with asthma(P<0.05);There was no correlation between FVC% pred and C-ACT scores in children with asthma(P>0.05).6.There was no correlation between Fe NO and C-ACT scores in children with asthma(P>0.05).7.There was a weak negative correlation between FEV1% pred,FVC%pred and the absolute value of Neu in children with asthma(P<0.05),and the remaining lung function indicators did not correlate with Ig E,Neu,Eos and Bas(P>0.05).8.There was a positive correlation between Fe NO and Ig E,Eos and Bas in asthmatic children(P<0.05),but no correlation with Neu(P>0.05).9.There was a negative correlation between C-ACT scores and absolute Neu values in children with asthma(P<0.05),no correlation with absolute Ig E,Eos and Bas values(P>0.05).10.There was a positive correlation between Ig E and absolute values of Eos and Bas in children with asthma(P<0.05),and no correlationwith absolute values of Neu(P>0.05).Conclusions:1.The lung function and C-ACT score can effectively assess the level of asthma control.2.Pulmonary function,Fe NO,and C-ACT are not completely interchangeable and can be used together to better assess asthma.3.Positive correlations exist between Fe NO and Ig E,Eos absolute values and Bas absolute values,suggesting that Fe NO,an airway inflammatory index,is closely related to serum inflammatory indexes.4.Monitoring the changes of blood total Ig E,EOS and Bas levels can provide reference for clinical diagnosis and treatment and condition monitoring of childhood asthma.