Causal Relationship Between Serum Uric Acid Levels And Periodontitis: A Two-sample Mendelian Randomization Analysis

BackgroundCurrent epidemiological research suggests a potential association between serum uric acid levels and periodontitis.However,the limited number of studies,insufficient evidence,and contradictory findings leave the relationship between the two subjects under debate.ObjectiveTo explore the causal relationship between serum uric acid levels and periodontitis through Mendelian randomization analysis using existing genome-wide association study(GWAS)data,providing reference for further research.Material and MethodsGWAS data on serum uric acid levels and periodontitis in European and Asian populations were included.Inverse-variance weighted method,weighted median method,weighted mode method,MR-Egger regression,MR-PRESSO,and MR-RAPS were used for Mendelian randomization analysis to determine the causal relationship between serum uric acid levels and periodontitis.ResultsMendelian randomization results for both European and Asian populations did not support a causal effect of serum uric acid levels on periodontitis,nor a causal effect of periodontitis on serum uric acid levels.The selected instrumental variables revealed no outliers or apparent horizontal pleiotropy.ConclusionThe findings of the Mendelian randomization analysis indicate no causal relationship between serum uric acid levels and periodontitis.