Effect Of Probiotics On Serum TMAO Level And Cardiovascular Risk Factors In Patients With Acute ST-segment Elevation Myocardial Infarction

Objective: To investigate the effects of oral probiotics on cardiovascular risk factors such as serum levels of trimethylamine-N-oxide(TMAO),total cholesterol(TC),triglycerides(TG),fasting blood glucose(FBG),and blood pressure in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods: Eighty patients with STEMI who were hospitalized in the Department of Cardiovascular Medicine of the First Affiliated Hospital of Hebei North University between January 2021 and October 2022 were selected consecutively as the study subjects.The study subjects were divided into an experimental group and a control group using a random number table method: basic information about all the study subjects was collected,and the control group was given standardized medication for STEMI,the experimental group was given oral probiotic preparations(Bifido,630 mg/time,twice a day)on the basis of standardized treatment,and both groups received continuous treatment for 12 weeks.The changes of serum TMAO,TC,TG,FBG levels,body mass index(BMI),blood pressure,and other indicators before and after treatment were compared between the two groups of subjects,and statistical analysis was performed using SPSS27.0 software.Results:1.There was no statistically significant difference between the experimental group and the control group in terms of general data such as gender,age,past medical history,smoking history,and diseased blood vessels(P>0.05).2.Before treatment: There was no statistically significant difference between the experimental group and the control group in serum TMAO,TC,TG,FBG,high density lipoprotein-cholesterol(HDL-C),low density lipoprotein-cholesterol(LDL-C),uric acid(UA)levels,BMI,and blood pressure(P>0.05).3.After treatment: The serum levels of TMAO,TC,TG,LDL-C,and FBG in the experimental group were significantly lower than those in the control group(P<0.05);There was no significant difference in serum HDL-C,UA levels,BMI,and blood pressure between the two groups(P>0.05).4.After treatment: The levels of serum TMAO,TC,TG,LDL-C,FBG,systolic blood pressure(SBP),diastolic blood pressure(DBP)in the experimental group were significantly lower than those before treatment(P<0.05);The serum HDL-C level was significantly higher than before treatment(P<0.05);There was no significant difference in serum UA level and BMI before and after treatment(P>0.05).5.After treatment: The serum levels of TMAO,TC,LDL-C,and SBP,BMI in the control group were significantly lower than those before treatment(P<0.05);The serum HDL-C level was significantly higher than that before treatment(P<0.05);There were no significant differences in serum TG,FBG,UA levels,and DBP before and after treatment(P>0.05).Conclusion:1.Probiotics can reduce serum TMAO levels in patients with STEMI.2.Supplementing probiotics can further reduce cardiovascular risk factors such as serum TC,TG,LDL-C,and FBG,and can be used as an adjunctive treatment for STEMI in clinical practice.