| purpose: To observe the clinical efficacy of acupuncture combined with medicine in the treatment of chronic insomnia of yin deficiency and fire hyperactivity type,compare the efficacy difference between simple application of traditional Chinese medicine and acupuncture combined with medicine,and explore the advantages of acupuncture combined with medicine in the treatment of chronic insomnia of yin deficiency and fire hyperactivity type,so as to provide theoretical and practical basis for clinical application.Materials and methods:the subjects of this study were all patients in the Department of encephalopathy of the Affiliated Hospital of Liaoning University of traditional Chinese medicine from October 2020 to October 2021.A total of 48 subjects who were diagnosed as chronic insomnia by western medicine and insomnia of yin deficiency and fire hyperactivity by traditional Chinese medicine were selected and included in this study.According to the ratio of 1:1,they were randomly divided into experimental group and control group,with 24 cases in each group.Both groups of patients were treated with Ziyin Anshen Decoction,one dose per day,decoction of 300 ml,taken three times in the morning,middle and evening,100 ml each time.On this basis,the experimental group was treated with acupuncture every day,5 days as a course of treatment,and the treatment time of both groups was 3 courses of treatment.The safety was evaluated before and after treatment.The changes of Pittsburgh sleep index(PSQI)single score and total score,Hamilton Anxiety Scale(HAMA)total score,Hamilton Depression Scale(HAMD)total score,insomnia severity index(ISI)total score and TCM syndrome product subscale score were observed before and after treatment.The clinical data obtained from the trial were statistically analyzed by SPSS 26.0 statistical software,and then the therapeutic effects of the two groups were compared.Result:48 patients with chronic insomnia of yin deficiency and fire excess type were observed in this study.During the test,3 cases fell off in the test group and 3 cases in the control group,with a total of 6 cases.Finally,42 cases were included in the statistical analysis,21 cases in the test group and 21 cases in the control group.There were no serious adverse events in both groups.1.Comparison of general case data and baseline data: before treatment,the gender,age,course of disease,PSQI score,HAMA and HAMD total score,ISI score,TCM syndrome score and other data of the two groups were compared.The difference was not statistically significant(P > 0.05),which was comparable.2.The scores of TCM syndrome and total score of TCM syndrome in the two groups were significantly lower than 0.05(the total score of TCM syndrome and total score of TCM syndrome in the two groups were lower than 0.05).3.Data analysis between groups: after treatment,there was no significant difference between the two groups in terms of sleep disorders,sleep drugs and daytime disorders in PSQI(P >0.05),but there was significant difference in sleep time,sleep time,sleep quality,sleep efficiency and total score(P < 0.05);The total scores of HAMA and HAMD were compared,and the difference was statistically significant(P < 0.05);The total score of ISI was compared,and the difference was statistically significant(P < 0.05);The scores of fatigue,irritability and five heart upset heat in TCM syndrome score table were compared,the difference was statistically significant(P < 0.05),and there was no statistically significant difference among other symptom groups(P > 0.05).4.Comparison of effective rates between the two groups after treatment: in the experimental group,8 cases were cured,7 cases were markedly effective,4 cases were effective and 2 cases were ineffective.The total effective rate was 90.4%.In the control group,3 cases were cured,2 cases were markedly effective,11 cases were effective and 5 cases were ineffective.The total effective rate was 76.1%.There was significant difference between the two groups(P <0.05).Conclusion:1.Ziyin Anshen Decoction can improve the overall sleep quality of patients with chronic insomnia of yin deficiency and fire excess type,and reduce the severity of insomnia,anxiety,depression and symptoms of yin deficiency and fire excess in traditional Chinese medicine.2.Acupuncture drug combination can improve patients’ sleep quality and sleep efficiency,prolong sleep time,shorten sleep latency,reduce the severity of insomnia,reduce patients’ anxiety and depression symptoms,and improve patients’ symptoms of fatigue,irritability and five heart fever.3.The clinical efficacy of acupuncture combined with medicine in the treatment of chronic insomnia with Yin deficiency and fire hyperactivity is better than that of simple Ziyin Anshen Decoction,which can be further tried in clinic. |
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