Observation On The Efficacy Of Xiangsha Liujunzi Decoction Combined With Netupitant And Palonosetron In Preventing And Treating Delayed Nausea And Vomiting Caused By Platinum-containing Chemotherap

Objective: To observe the efficacy,effect and safety of Xiangsha Liujunzi decoction combined with netupipitanpolosetron capsules(NEPA)on late-onset nausea and vomiting caused by platinum-containing chemotherapy.Methods: According to the inclusion criteria,the 90 patients included were randomly divided into an experimental group and a control group,with 45 people in each group.The experimental group was treated with Xiangsha Liujunzi Decoction combined with NEPA,while the control group was treated with NEPA regimen to prevent nausea.Main endpoints: the complete remission rate and effective rate of nausea and vomiting symptoms in patients 2-5 days after receiving chemotherapy,the severity of nausea and vomiting symptoms in the two groups,the number of rescue Sex therapy used in the two groups,and the duration of nausea and vomiting in the two groups.The secondary endpoint of the study was appetite,traditional Chinese medicine syndrome score,KPS score,and incidence of adverse reactions.Results: 1.The complete remission rate and effective rate of vomiting in the experimental group during the delayed period were higher than those in the control group.There was a statistically significant difference in the complete remission rate of vomiting between the D2,D3,D5 and total delayed periods,as well as the effective rate between the D2-D4 and total delayed periods(P<0.05).2.The complete remission rate and effective rate of delayed nausea in the experimental group were higher than those in the control group.There was a statistically significant difference between the two groups in D2-D5,total delayed nausea complete remission rate,and D2-D4,total delayed nausea effective rate(P<0.05).3.The number of cases of grade I and II vomiting and nausea symptoms in the experimental group D2-D5 was lower than that in the control group,and the number of cases of grade 0 vomiting and nausea symptoms was higher than that in the control group.In terms of vomiting level,there was a statistical difference between the two groups D2,D3,and D5(P<0.05),and in terms of nausea level,there was a statistical difference between the two groups D2-D5(P<0.05).4.The number of patients receiving rescue treatment in the control group(2 cases)was significantly lower than that in the experimental group(9 cases),and the difference between the two groups was statistically significant(P<0.05).5.The duration of nausea and vomiting in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.05).6.The effective rate of appetite regulation in the experimental group D2-D5 was higher than that in the control group,and the difference was statistically significant(P<0.05).7.There was no statistically significant difference in KPS scores between the two groups before treatment(P>0.05),but after treatment,the KPS scores in the experimental group were significantly higher than those in the control group,with a statistically significant difference(P<0.05).8.There was no statistically significant difference in the TCM syndrome scores of the two groups before treatment(P>0.05).After treatment,the TCM syndrome scores of the experimental group were lower than those of the control group,and the two groups had statistical significance(P<0.05).9.In terms of adverse reactions,the incidence of indigestion,fatigue,and diarrhea in the experimental group was significantly lower than that in the control group,with a statistically significant difference(P<0.05);The incidence of leukopenia,anemia,liver function damage,kidney function damage,hiccup,constipation,insomnia,drowsiness,elevated blood sugar,and abnormal blood pressure between the two groups was not statistically significant(P>0.05).Conclusion: 1.In terms of the efficacy of preventing delayed onset CINV caused by platinum drugs,the objective relief rate and effective rate of nausea and vomiting in the Xiangsha Liujunzi Tang combined with NEPA group and NEPA group were both higher.The objective relief rate and effective rate of nausea and vomiting in the combined group,the severity of nausea and vomiting patients,the number of people treated with rescue drugs,and the duration of nausea and vomiting were significantly lower than those in the experimental group.The difference between the two groups was statistically significant.The combination of Xiangsha Liujunzi Tang and NEPA patients has a lower incidence,weaker severity,and higher tolerance of nausea and vomiting,and can reduce the duration of nausea and vomiting in patients.2.The combination of Xiangsha Liujunzi Tang and NEPA group showed better improvement in appetite,KPS,and overall TCM symptom scores compared to the NEPA group alone.Xiangsha Liujunzi Tang combined with NEPA can improve patients’ quality of life.3.There is a certain difference in adverse reactions between the two groups.The incidence of indigestion,fatigue,and diarrhea in the Xiangsha Liujunzi Tang combined with NEPA group is significantly lower than that in the NEPA group alone,with no serious adverse reactions and high safety.