| Biological 3D printing is a bottom-up manufacturing method based on additive manufacturing.Currently,biological 3D printing is in a rapid development stage,and its research results are widely applied in drug research,scaffold manufacturing,pathological research,and other fields.It is developing towards in vitro tissue and organ manufacturing,with broad development prospects.After more than 20 years of development,biological 3D printing technology has made great progress,but each manufacturing method has its limitations.Currently,biological 3D printing also faces problems such as limited categories of biological ink,cumbersome printing processes,low printing accuracy,and high operational difficulty.In summary,the performance of biological 3D printing devices is currently one of the main reasons limiting the development of biological 3D printing.Based on the current development status of biological 3D printing equipment and practical research,this article designs a fully functional multi-nozzle biological3 D printer,aiming to provide a new solution for the development of biological 3D printer and promote the development of related technology for biological 3D printer.The main work done to achieve the above goals is as follows:(1)A fast detachable nozzle module has been designed,and three types of nozzles,namely high temperature,low temperature,and photocuring,have been designed to cater to a larger range of printing materials.In addition,by studying and comparing the distribution of fluid velocity,shear stress,and steady-state pressure of different barrel structures when printing the same material,a more biologically friendly barrel structure was designed,and aluminum alloy was selected to make the barrel.(2)This paper designs a hardware solution for the biological 3D printer control system,which mainly includes two parts: circuit control system and pneumatic control system.The hardware scheme of the designed circuit control system simplifies the control mode of the printer by centralizing the control of the main components in the main controller;The pneumatic control hardware scheme is designed through functional analysis,overall scheme design and analysis and selection of relevant components.The designed scheme can not only provide accurate positive and negative pressure for the nozzle,but also control the movement of the nozzle up and down.(3)This paper develops a software solution that is compatible with the hardware of the biological 3D printer control system The software solution mainly includes the development of the upper computer slicing software and the compilation of the main controller firmware.The development of slicing software follows the principle of convenient use,and a personalized UI interface has been developed.Algorithm research has been conducted using two commonly used scaffold models as slicing objects,achieving the function of directly generating slicing code by inputting model parameters,which has the advantage of convenience and speed.The compilation of the main controller firmware is based on the control system hardware,where Marlin firmware is cropped and rewritten,and uploaded to the main controller for debugging,achieving precise control of the printer.(4)A prototype of the biological 3D printer was constructed,and the various performance of the printer was tested through temperature control experiments,nozzle withdrawal experiments,and model printing experiments,verifying that the multi-nozzle biological 3D printer has good printing performance. |
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