Clinical Study Of Jia Zujin 's Academic Thought And Clinical Experience And Treatment Of Children With Cough Variant Asthma

Research purposesExcavation the academic thoughts and clinical experience of Jia Liu-jin, who is the elder Traditional Chinese medicine experts in the academic experience inheritance instructor, famous expert of Shanxi Province, and Chief physician of the Affiliated Hospital of Shanxi University of Traditional Chinese medicine. Combing the mentor’s academic origin, concise academic thought, and sum up clinical experience. Understand the idea and methods of the tutor, clarify the learning experience, and deepen the understanding, in order to improve our own diagnosis and treatment level of disease. Infantile pulmonary disease is common and multiple, especially children with chronic cough caused by cough variant asthma, which the incidence increased gradually and occupies in the first place, affecting children’s physical and mental development. Around the infantile pulmonary disease, thoroughly and systematically summarize Jia Liujin’s treatment to further observe medication rule and summarize the experience of mentors in the treatment of children with cough variant asthma. And then further evaluate the clinical efficacy of xuanqinghuatan soup in treating children’s cough variant asthma. The research will provide effective treatment for the prevention and treatment of pediatric pulmonary diseases by TCM, especially enrich the treatment of children with cough variant asthma and provide theoretical basis, and explore effective research model for elder Chinese medicine academic thought and clinical experience inheritance.Research contents and methods1 Combining the theoretical research and clinical practice to sum up and concise Jia Liu-jin director’s academic thought, summarize the clinical experience.Through ways like literature survey, following tutor’s outpatients, medical records reorganization, listening to lectures of teacher, clinical observation and combine with in-depth interviews and many other kinds of aspects, than highly condensed the academic thought of director Jia Liu-jin, summarized clinical experience of tutor in diagnosing and treating in pediatric diseases, especially systematically summarized tutor’s treatment experience surrounding pediatric pulmonary disease. To reflect the tutor’s application in clinical from the system of disease, syndrome,prescription and medicine.2 Retrospective analysis of Jia Liu-jin’s drug regularity in treating children’s cough variant asthma.Taking the clinical cases of cough variant asthma in children as the research object, using the method of retrospective study, and EXCEL and SPSS data mining, clustering analysis method and association rules to analyze the rule and experience of the medicine use in the treatment of children with cough variant asthma.3 Prospective cohort study to evaluate the efficacy of the xuanqinghuatan soup in treating of children with cough variant asthma.To evaluate the clinical effect of the treatment of children with cough variant asthma by using prospective cohort study. Select the special clinic and outpatient in Pediatrics department of the Affiliated Hospital of Shanxi University of Traditional Chinese medicine from March 2014 to March 2015 in children who was diagnosed as cough variant asthma and met the inclusion criteria. In exposure group, divide cases into treatment group and control group and attribute into the queue. The treatment group was treated with oral "Xuanqinghuatan" soup, and the control group was treated with Montelukast Sodium. The observation period is 21 days. To evaluate the curative effect of cough severity, the total score of the symptom and recurrence of the end point. Statistical analysis method:application of SAS statistical analysis system.Results1 Jia Liu-jin’s academic thought originJia Liu-jin, director of the new China, as the initial generation of traditional Chinese medicine, has played a positive role in promoting the development of Chinese medicine, he has made an indelible contribution to the development of traditional Chinese medicine of Shanxi. The formation of his academic thoughts based on learning systematically, following the teacher and the academic basis of diligent in clinical and summarize the experience timely. He follows the old adage, learns widely from others strong points, especially the 4 classical pediatric books, which are Xiaoer yaozhengzhijue, Youkefahui, Youyoujicheng, Youkezabingxinfayaojue attached by Yizongjinjian. Meanwhile, he deeply affected by his mentor, Professor Li Hanqingand Professor Zhang Guangyu, and has worked conscientiously in clinical and has accumulated bit by bit for 50 years. Finally form the academic characteristics of the diagnosis and treatment.2 Liujin Jia’s academic thoughts and clinical experience summary2.1 Liujin Jia’s academic thoughts2.1.1 combination of Chinese and Western medicine and complement both of their advantage: The thinking mode of combination between Chinese and Western medicine is the efficient methods to study disease.Only by taking each other’s advantage for use and reasonable combination, can improve the clinical efficacy.2.1.2 Pay attention to the combination, inheritance and innovation:Teacher Jia is good at using combination mode, gives us a key to open the door to innovation. He learns from the ancients and not constrained by the ancients, not only inheritance but also innovation. On the basis of recognize disease, combination of different syndrome and treating methods and prescription, he can improve the clinical effect.2.1.3 Synthesis of the four diagnostic methods and attaches great importance to the inspection: Teacher Jia values inspection occupies’important position in pediatrics. He absorbs all advantages of each famous doctor, not only has sole opinion to expression, color, shape, and state, but also dig the content about children’s mouth, throat, Qi, color, and the finger index. According to these information, he can be better guided in clinical syndrome differentiation.2.1.4 Recognize diseases from various aspects and syndrome differentiation dynamically: Based on the combination of disease and syndrome and pay attention to the system of disease-syndrome-prescription-medicine, he can recognize diseases from various aspects, and learn the variation changes of syndrome, so that it will guide the disease’s prevention and treatment.2.1.5 Viscera treatment based on syndrome differentiation, outstanding lung and spleen. Jia is good at using viscera differentiation method for guiding the clinical therapy, and emphasizes each syndrome have the focus, we must identify the main aspects so as to guide effective treatment. For children’s disease, lung and spllen are often insufficient, we should focus on the links between the two aspects in order to guide the syndrome differentiation for common disease.2.1.6 Application of the compound multiple methods and good at reconciliation and heat-clearing method:Jia uses many kinds of methods, especially和法?, so that the surface and inner parts can both be harmonic, meanwhile, pay attention to deficiency and in-deficiency, lung and spleen. In addition, because pediatric has more warm disease, so he prefer using clearing method, and he treats patients according to the difference of viscera, location and stage.2.1.7 Compound prescriptions often give additional effects:Jia is good at using compound prescription, especially compound prescription which is combined with two drugs, to enhance the effect on the basis of differentiate the mean treatment and secondary treatment. He also gives prescription according to the syndrome, and is good at using drug-group in order to enhance the effect and alleviate the toxic.2.2 Summarize Jia Liu-jin’s clinical experience in treating pediatric diseases: Comprehensively and systematically summarize Jia’s treating experience of pediatric disease by arranging the clinical cases which are relative with pulmonary system diseases include six kinds, ie, pneumonia pant cough, asthma, recurrent respiratory tract infection, pleurisy, chronic cough, cough variant asthma, and 5 complex and difficult diseases(conclusion, epilepsy, cerebral palsy, allergic and purpura). Reflect the academic thought and treating characteristic in diagnosis and treatment from the system of disease-syndrome-prescription-drugs. The very period of pediatric pneumonia pant cough need pay attention to pathogenic heat obstructing the lung, pay attention to the later period nursing. Repeated respiratory tract infection use He methods, and the prescription of Fuganling get great effect. Asthma is treated with three stages, acute period should use western medicine first, lasting period should focus on differentiation of cold and heat, and the chronic period should pay attention to the toning of lung, spleen and kidney. Cough variant asthma values eliminate phlegm. Chronic cough should combine disease differentiation with syndrome differentiation and pay attention to the diagnose of disease and differentiation of syndrome. Treatment of pleurisy emphasize the treatment dependent on the stage, clearing and complementary separately and pay attention to He methods. In the experience of pediatric pulmonary diseases, summed up the twelve treatment of the lung diseases. Discussing the application of the three Decoction which made up by tutor Jia(yinchaituire soup, jiedutounong soup, jiaweicangerzi powder), And select Jia’s six commonly used groups of traditional Chinese medicineusing, then describes the essence of the herbal prescription.3 Jia Liu-jin’s Clinical study in the treatment of children with cough variant asthma3.1 Discussion and analysis of Jia Liu-jin’s drug regulation in treating children with cough variant asthma:Through the analysis of the 76 cases of the 160 prescriptions, there are 53 Chinese drugs have been used, and totally has been used 2057 times. By using clustering analysis, we obtain 5 s groups, and most of them are appeared in the drugs which can clear phlegm and stop coug. There are 12 Chinese drugs frequently used more than 50%, and other 12 Chinese drugs are used between 10%-50%. The medicines mainly belong to lung, spleen and stomach meridians, which includes 42 kinds belonging to the lung, used for 1667 times, and occupy 81% of the total frequency, and 79.24% of the total drug number. Clementine association rules shows herbs about mahuang, xingreng, gancao, chenpi, fuling, jiangbanxia, jiegeng, beimu,dillong, ziwan, donghuahave consanguineous connection。3.2 The clinical study of Xuanqinghuatan decoction in treating pediatric cough variation asthma:there were totally 69 cases, and 34 cases belong to control group, and 35 cases belong to treating group, and 8cases are lost.The total cases used with statisticalmethods are 61. The degree of cough are graded by visual analog scale. Before treatment, the treating group is 6.52±1.02.After treatment, treating group is 2.14±1.38. Before treatment, the control group is 6.44±1.10. After treatment, the control group is 2.94±1.62. The difference is statistically significant between treating group before and after treatment.3 weeks after treatment, the two groups’is lower than 0.05. For the influence of syndrome total score, before treatment, the treating group is 23.34±2.70.After treatment, treating group is 8.66±3.89. Before treatment, the control group is 22.78±2.47. After treatment, the control group is 11.78±4.72. After treatment, the total score of two groups is lower than 0.05. For the total efficiency between control group and treating group, treating group is 93.10%, and control group is 81.26%. There is no statistic difference between the two groups.Conclusion1 Liujin Jia, diligent in thinking and learning, learns widely from others, by reading the classics, learning with famous doctor, more than fifty years working experience, won the truth forms the systematic academic thought, has accumulated rich clinical experience. Tutor had unique understanding of internal medicine, surgery, gynecology and pediatrics, specializes in pediatrics, specializes in the diagnosis and treatment of children with lung, infectious diseases and miscellaneous diseases. Systematic summary of the treatment of pediatric pulmonary disease, which greatly enriched the research content of pediatrics of traditional Chinese medicine, through the excavation of tutor’s academic thought and clinical experience, improve my cognition and clinical level, and promote the development of modern Chinese medicine, while there are a lot of valuable experience needed to further finish and develop.2 Liujin Jia treats children with cough variant asthma attach importance to children’s physical characteristics, highlights the treatment in lung and spleen of his academic thought, based on the insidous phlegm, focusing on ventilating lung and tonifying the lung, resolving phlegm and relieving cough, pays attention to utilizing the compound, skillfully use the messenger drugs, it is worth learning and application.3 His self-created "Xuanqinghuatan" soup can effectively relieve cough degree in children with cough variant asthma, improve the symptoms and have exact effect. However, further optimization of clinical research methods is needed to further confirm the mechanism of action. This study indicates that Qingfei is effective treatment to cure this disease and enrich the theory and treatment of cough variant asthma.