Study On The Factors Influencing The Dosage Relationship Of Ginger And The Difference Of Human Drug Reaction

ObjectAt present, the researches of related organic factors about individual differences in drug responses mainly were experiences summary and animal experiments, lacking of syste matical survey and analysis, which still remained purely theoretical. There is seldom res earch about human trials and objective analysis. This research took ginger for exampl e, adopted human trails with clinical infrared thermal imaging technology, observed subj ects’relative temperature difference of middle jiao in infrared thermal imaging after taki ng ginger to see ① if there were differences curative effect in different person and an alyzed organic factors concerned with the difference. ② The dose-effect relationship of ginger’s warming middle jiao. Took ginger for example, adopted human trails with cli nical infrared thermal imaging technology, compared subjects’relative temperature differ ence of middle Jiao in infrared thermal imaging after taking ginger with low dosage, m iddle dosage and high dosage. Discussed dose-effect relationship based on human. ③ The comparison of the efficacy of fresh ginger and dry ginger. Based on the human t rails, to study the difference in pharmacological activities between fresh ginger and dry gin ger, compared the efficacy of warming middle Jiao and warming Yang, provide directi on and an experimental basis to improve the rational use of medicines.Methods① Observed the changes of subjects’ relative temperature difference of middle jiao in infrared thermal imaging after taking ginger and plot the change value’s scatter chart to see if there were different curative effects in different person, then divide into two gr oups that were good response group and bad response group. Meanwhile, dividing all the subjects into good response group and bad response group based on subjects’ sel f-perception for abdominal temperature. Compared the two kinds of classifications with four table match chi-square test. Collected subjects’ related organic factors including sex, age, smoking, drinking, blood type, native place, anxiety, allergy, BMI (body mas s index), BFR (body fat ratio), BPR (body protein ratio), inorganic salts ratio, BWR (body water ratio), BMP (bioelectrical metabolism rate) etc. through the questionnair e covers basic information, Constitution classification and determine scale, SAS (self-r ating anxiety scale) and body composition analysis. Divided subjects into good respon se group and bad response group with reference to the results of clinical infrared therma 1 imaging technology, and then used single factor analysis and the multivariate logistic r egression analysis to search for the related organic factors. ② The experiment was in a Latin Square design. Every subject had received ginger granules with the same temp erature in low dosage, middle dosage and high dosage, observed the differences in eff ect of worming middle jiao with different dosages. Researched dose-effect relationship use Latin Square analysis. ③ Using randomized, single-blind, controlled clinical trial method and clinical infrared thermal imaging technology, compared the changes of subje cts’relative temperature difference of middle Jiao and Du mai between test group (fres h ginger and the control group (dried ginger), which were regarded as the standard of effi cacy of warming middle Jiao and warming Yang, T tests were performed to determin e whether significant differences occurred in fresh ginger and dried ginger.Result① According to the scatter chart of subjects’ relative temperature difference of middle jiao in infrared thermal imaging after taking ginger, indicated that there were obvious differences in effect of worming middle jiao between different person. There were inconsistent results between infrared detection and subjects’ self-perception. The main organic factors relating to individual differences in drug responses were age and BMR, the other factors such as sex, BMI, smoking, drinking, blood type, native place, anxiety, allergy have a relatively small impact on drug responses. The OR of age was less than 1, which was a protective factor. It showed a negative correlation between age and drug effect. The OR of BMR was more than 1, which was a risk factor. It showed a positive correlation between BMR and drug effect. ② At some extend, within 50g/time, ginger’s efficiency of worming middle jiao increased with higher dosage. The dose-effect relationship had positive liner relation. But considered the volunteers’ acceptance, the experiment used most dosage was 50g/time and did not get the effective peak. How about the dose-effect relationship after peak effect, the experiment did not be involved. ③ Dried ginger had obvious curative effect of warming middle Jiao and warming Yang, but fresh ginger had not. Dried ginger’s warming middle Jiao was superior to fresh ginger.Conclusion① There were obvious individual difference in drug effect. We should aim at individu al difference in clinic to achieve the real sense of Individualized treatment. The patients’ self-perception, especially perception for cold and warm, has a certain reference value for doctor’s syndrome differentiation. But doctors can not totally rely on patients’ self-perception, should synthesis of the four diagnostic methods and then discriminated cold and warm consulting others syndromes, tongue and pulse. The main organic factors rel ating to individual differences in drug responses were age and BMR. There were negati ve correlation between age and drug effect, positive correlation between BMR and dru g effect. Doctors should fully consider these factors at syndrome differentiation and treat ment dosage and not blindly pursuit big dosage or small dosage. Using small dosage that who are sensitive for drug effect and big dosage who are tolerance to drug effec t. ② There were very close relationship between dosage and effect. At some extend, wi th the drug’s dosage increased, the effect was enhanced. When the patient was serious ly ill, should be used big dosage to enhance curative effect. ③ There were significant differences between fresh ginger and dried ginger. The practice that dried ginger instea d of fresh ginger had not the rationality. Dried ginger had obvious curative effect of w arming middle Jiao and warming Yang, but fresh ginger had not or had little. That w as the drug reason why individual difference of ginger’s warming middle Jiao was so obvious. If the efficacy of fresh ginger seemed to be more focused on relieving exteri or needed to be further researched.