Research On The Distribution Of Functional Constipation Syndrome And The Law Of Party Formation Based On Unsupervised Data Mining

Research purposesThis research based on unsupervised data mining methods, through clinical cases information collection and based on data mining with traditional Chinese medicine inheritance support system, using multiple statistics method for analysis and summary, respectively through research ancient physicians treating constipation prescription laws,and research TCM Syndrome distribution of functional constipation and research prescription law of treatment functional constipation by Professor Ding Xia based on TCMISS, multi-dimensional summed treatment of functional constipation of new ideas and new strategies to provide a reference constipation for clinical treatment of functional constipation to enhancing clinical efficacy.Research methods1) Document Origin:using philological methods, by collecting TCM literature, systematic analysis of the evolution of constipation nonaggressive, etiology, pathogenesis, syndrome, treatment, prescriptions, striving to understand the development law of syndrome differentiation and treatment of constipation as a whole.for the study of Philology laid the foundation.researching prescription laws of treatment constipation with unsupervised data mining methods based on the "Dictionary of Chinese medicine prescription",screening from "Chinese medicine prescriptions Dictionary" collection contains prescription treatment of constipation prescription 478,filtering from "Chinese medicine prescriptions Dictionary" in the containing of prescription treatment constipation of prescription 478 first, using TCMISS (V2.5) "data analysis" module in the "prescription analysis" function, followed by for "frequency statistics", and"prescription analysis", and "new prescription analysis" processing in 478 prescription,covering a pharmaceutical frequency statistics, drug-drug association rules analysis, complex system entropy clustering data mining methods.2) Clinical research:using epidemiological cross-sectional research method, designing Case Report Form,referencing to the Rome III standard diagnostic criteria for functional constipation and syndromes classified according to the Chinese Medical Association Branch of the spleen and stomach disease, and there are two physician supervision of senior titles recognizing.Revenuing from May 2014-November 2015 from the Beijing Chinese medicine hospital affiliated to capital Medical University, Beijing University of Chinese medicine, Dongzhimen hospital, China Academy of Traditional Chinese medicine hospital, Wangjing collected in line with inclusion and exclusion criteria for patients, a total of 109 cases, counting constipation in patients with male-female ratio, calculating the proportion of each syndrome, using multivariate statistical methods to analyze and summarize, exploring the functional constipation syndromes distribution.3) Clinical Inheritance:studing prescription law on TCMISS of Professor Ding Xia treatment chronic constipation, establishing constipation database, and then use analysis system software, data mining, using the frequency statistics, improvement of mutual information, complex system entropy poly class and unsupervised hierarchical clustering methods such as entropy, counting on drug frequency, the data results of drug-correlation coefficient, analyzing these results, preliminary draw core pharmaceutical composition for the treatment of constipation and clinical reference new prescription.Research result1) Syndrome Distribution Laws of functional constipation in TCM include:(1) general information on the situation:The study enrolled a total of 109 cases, of which 20 were males, 89 females, male to female ratio is about 1:4.45. Maximum age 70 years, minimum 18 years, mean 42.82 years old, and the average age of male was 47.10 years, the average age of women was 41.85years. The age distribution in the youth group 18-35 age group is the largest proportion, accounting for 41.28%, the middle age group 36-55 age group accounted for 32.11 percent, followed by the elderly group 56-70 age group the proportion minimum of 26.61%. From the professional distribution, up to the staff, a total of 38 cases (34.86%), retired 26 cases (23.85%),19 cases of cadres (17.43%), followed by the unemployed, students, workers, farmers. Consider the long-term work in the office, less activity related. (2)medical history:The durations of disease were less than 1 year (including 1 year) accounted for 12.85%,2-5 years accounted for 41.28% and 6-10 years accounted for 27.52%,11-20 years accounted 12.85%,21--50 years accounted for 5.50%. Diet partial addicted distribution situation:addicted to food Feiganhouwei accounted for 29.36%; eating spicy accounted for 22.93%; drinking less accounted for 17.43%, accounted for 15.60% addicted to cold drinks, eat fine food accounted for 14.68%. (3) By using cluster analysis of statistical Syndrome will combine elements of traditional Chinese medicine theory of knowledge and clinical experience will be divided into four types syndromes. The most is hot syndrome Constipation patients, accounting for 47.70 percent, followed by Qi Constipation accounted for 26.61%, virtual Constipation accounting for 22.02%, cold Constipation accounted for 3.67%minimum. By functional constipation Syndrome Distribution we recognize that functional constipation syndromes distribution of evidence-based patient with the syndrome is proportional to the resulting macroscopic clinical cases, helping to further guide clinical treatment.2) Group of party regularity of prescription constipation By researching the law of constipation prescription from "Chinese medicine prescriptions Dictionary",it found that statistic out of the top 10 drugs used frequently as Dahuang Gancao Danggui Zhiqiao Huomaren,Huangqin binglang Muxiang Chenpi Chuanxiong.Based Prescription law association rules analysis, summed up the use of a higher frequency of drugs on the top 10 were "Gancao -Dahuang" "Huangqin-Dahuang" "Danggui-Dahuang" "Dahuang-Zhiqiao" "Gancao -Danggui" "Mangxiao-Dahuang ""Huangqin-Gancao ""Zhizi-Dahuang ""Shengdi -Danggui ""Muxiang-Binglang ",a high correlation of drugs on the Huangqin, Zhizi-Danghuang, Mangxiao-Dahuang. Based on a combination of core complex system entropy clustering analysis, extract the core pharmaceutical composition 16, using Entropy unsupervised hierarchical clustering analysis to obtain new prescriptions 8. At the same time through literature mining discovery, it was also in the "Chinese medicine prescriptions Dictionary" according to Song Yuan Ming and Qing Dynasties physicians treating constipation prescription is compared, combined with modern medical treatment of chronic functional constipation awareness can be seen, for the treatment of constipation Qi, diarrhea using Chinese herbs is gradually decreased, while the intestines, nourishing Yin in Chinese medicines is becoming a mainstream treatment of constipation.3) By researching the law of Professor Ding Xia’s constipation based on TCMISS it discovery:Professor Ding Xia’s 106 constipation prescription drugs in the frequency statistics, frequency of 10 before using medicine as Zhishi Zhiqiao Huzhang Zisuzi Sharen Zisugeng Shenggancao Laifuzi Muxiang Huomaren.Prescription-based law association rules analysis, the first nine are "Zhishi-Zhiqiao", "Zisuzi-Zisugeng", "Zhishi-Zisuzi", "Huzhang-Zhiqiao" "Huzhang-Zhishi" "Zisuzi-Sharen" "Zhiqiao-Zisugeng" "Zisuzi-Zhishi", a high degree of relevance for the drug to"Zisuzi-Zisugeng". Based on a combination of core complex system entropy clustering analysis, extract the core pharmaceutical composition 14, using Entropy unsupervised hierarchical clustering analysis to obtain new prescriptions 7. Ding reflects good use gas medicine, clinical Xiangsu Powder-based administration features.Research Conclusionl)With the changing times, the pathogenesis of constipation is changing, its pathogenesis is not limited to disorders of Qi, Ding believes that with the improvement of living standards, the nature of the gastrointestinal disease has also undergone a fundamental change to tobacco and Feiganhouwei increase gastrointestinal damage, and secondly, to speed up the pace of life, mental stress increased, affecting the liver catharsis, and then the fire. So Heat syndrome of spleen and stomach disease, positive also majority,which clinical syndrome distribution from the survey also verified.2) Professor Ding puts healthy management concepts into clinical medicine treatment, emphasizing chronic culprit is lifestyle, in which diet is one of the important causes of gastrointestinal disease in recent decades.China’s diet from the traditional "grain grains "to the West" meat and milk "paradigm shift, which bring a dramatic increase in chronic diseases. With Literature and clinical it can be found that:food restriction and dietary changes can effectively improve constipation and eliminate the "stool".Long-term holding half-full half-hungry, and out of balance state from Confucian speaking is in line with "moderate" way.the modern medicine also verify the state of semi-starvation which can activate longevity genes prolonging life.3) Constipation clinical must includes dry and sticky types, whose performance of constipation unreasonable or poor bowel movementFrom the "Dictionary of Chinese medicine prescription" medication to Professor Ding’s style changing, even from the Song and Yuan Ming and Qing Dynasties doctors’ constipation prescription change can be seen, for dry and stressed intestinal constipation Jin dry, Qi-block, advocated the use of FengShuYuRun method;Wet-Hot constipation, constipation in this part of a special type, had been addressed but not cause the ancients attention.Now quite common clinical, often with Feiganhouwei partial eclipse spicy, emotional disorders,and so on, easy to loss of government mistreatment and difficult to eradicate.To some extent, it’s associated with Metabolic Syndrome,which performance was full of heat, so changing life-stye is an important part of life,.For this constipation, it should be treated with Kaiyuqingre,Yunpiqushi, coupling with a good diet restriction therapy which can improve the outcome.4) With the use of modern data mining methods,for the ancient medical books and Professor Ding outpatient treatment of constipation prescription,they use frequency statistics, improved mutual information, complex system entropy clustering, unsupervised entropy hierarchical clustering and other methods of analysis, its feasibility and scientific nature for the clinical treatment of constipation to provide some reference value. TCMISS plays an important roles in achieving some other agents as Auxiliary entry, management and analysis in the study of traditional Chinese medicine prescription rules and discovering new prescription. The core portfolio and alternative new prescription for clinical or basic provide useful clues, but which still need traceability, clinicians interpretation, clinical trials and other studies to further evaluate.