| Percutaneous hot fluids injection therapy has been used to induce coagulation tumour necrosis by direct thermal contact. At present, the investigation for the therapy is not adequate, so its clinical application is limited. Additionally, because of the small size of the inducible coagulation necrosis, this treatment modality is effective in destroying tumours smaller than 2cm in diameter, larger tumours are incompletely destroyed and recurrence occurs in these lesions.Therefore, increasing the region of induced coagulation to enable the treatment of larger tumours is critical in the research of this modality. The purposes of the experimental study were to evaluate ?the pathological, radiological changes and effects on liver function after percutaneous hot saline injection therapy(PSIT) in dog liver,(.~j) the effects of blood flow on lesion size in PSIT through eliminating hepatic arterial, portal flow and temporary occlusion of the hepatic vein, ?the value of percutaneous hot ethanol and acetic acid injection therapy. 1. Hot saline with different dose was injected into dog livers in vitro. In addition, 1 5ml of hot saline was injected into 14 dog livers in vivo, the animals were followed up for 1?5 days with liver function test, CT, MRI, gross and microscopic examinations.The results showed that the lesion size increased with increasing dose of hot saline injected at the range of 2?2 ml, but there was obvious fluid reflux when dose of injection was above I Oml. There was no significant elevation of ALT, AST, GGT and ALP level after the procedure (P>O.05). Pathologically, three zones(the central zone, coagulated zone and congestive, haemorrhagic zone) could be distinguished in the area of III coagulation. Large vessels and bile ducts contiguous to the lesions were always intact. The treated area showed decreased density on unenhanced CT, and no enhancement on contrast-enhanced CT. Peripheral enhancement rim could been seen in all lesions after PSIT. The treated area demonstrated a low- intensity area on Ti -weighted images, and a high-intensity area on T2- weighted images. The treated areas were devoid of gadolinium enhancement, and a peripheral enhancement rim surrounding the region of coagulation also could been seen. 2. The effect of temporary balloon occlusion of a hepatic vein on blood flow of the liver was evaluated with dynamic and dual-phase spiral CT scanning in 6 dogs. Twelve healthy dogs were randomly divided into three groups: uninterupted hepatic blood flow( groupl), hepatic artery and portal vein occlusion( group2),and hepatic vein occlusion (group3). 8m1 of hot saline was injected into the liver. Temperature in the treated area and lesion size were measured after saline injection. Contrast-enhanced CT scanning performed with hepatic vein occlusion showed the density in the area of hepatic venous occlusion was much lower than that in the nonoccluded area, and there was a well-demarcated border between the two areas. Retrograde opacificaton of the portal vein in the occluded area was seen. Peak time of enhancement for the hepatic parenchyma and the main trunk of portal vein in the occluded area was prolonged compared with that in the nonoccluded area. CT findings above indicated that with the hepatic vein occlusion, hepatic blood flow in the occluded area was reduced and slowed down. Tissue temperature in the treated area decreased more rapidly in group 1 than in gro...
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