Study On The Mechanism Of Improvement Of Early Biabetes Mellitus Rat Kidney By T.S.K

It studies the mechanism that T.S.K acts on diabetes kidney blood dynamics of the rats of STZ in this subject. Especially after observing STZ' s influence on the active material level of blood vessel, which is closely related with regulations of kidney blood dynamics, it is inquired into that S. T. K' s beneficial functions on kidney, spleen and recuperation. The symptoms of diabetes and kidney disease are similar to those of "subdue thirsty diseases" , "hydroncus" , "urine turbid" , "consumptive disease" in traditional Chinese medicine. On this basis, S. T. K with Deficiency of both spleen and kidney, Obstruction of collaterals by blood stasis as main symptoms, with eliminate evils for supporting vital Qi* reinforce and reduce concurrently as main treatment principles, choosing ginseng, Ligusticum wallichii, Huang Jing, GeGen, leech, motherworts as indigents of medicines, is helpful to prevent and cure diabetes and kidney disease in the early period.Using diabetic heavy mice with STZ abdominal injection as animals' model, Lotensin as positive contrast group, we compare a series of indexes with those of the T. S. K treatment after four weeks. The blood sugar, blood insulin, urine micro-albumin, urine Bs 2 little globulin, blood skin acid anhydrides & blood urine nitrogen, kidney serious /weight will be tested, PANP> renin activity^ AngIIexpress level, are tested with radiation immunity method; the average value of Diameter ofgloraerulus' s, the Diameter of glomerulus' s, the indigents charge in kidney organization (NOS-renin activity) are tested by photon-microscope; the influence on pathological change of glomerulus is tested by electro-microscope.The result shows: T. S. K helps to improve and regulate blood insulin, blood sugar and kidney function; the average sphere of glomerulus and the Diameter of glomerulus' s has an obvious improve; the level of active peptide materials in blood vessel is reduced; Nitricoxide synthase-renin activity of kidney organization is reduced; Comparing with the heavy mice in model group, the differences are distinctive (p<0.05 or p<0. 01),and T. S. K can relieve or restrict the pathological change of heavy mice under photon-microscope and electro-microscope.The conclusion: T. S. K helps to improve the unusual phenomena in diabetic blood dynamics of kidney. Regulating active peptide substance express level of blood vessel through various kinds of methods is one of T. S. K' s major functions in preventing and curing diabetes and kidney diseases.