| Hyperbilirubinemia is a kind of serious complication induced by viral hepatitis. The first, this research analysed the literature of ancientry, present-day and contemporary, and also analysed the present-day research fruits. The conclusion shows that the pathogeny and pathogenesis of hyperbilirubinemia induced by viral hepatitis is dampness and heat, toxins and stagnant blood. And dampness and heat is its essential pathogeny, while toxins and stagnant blood are produced during its progress. And the pathological changes lie in liver, gallbladder, spleen, stomach, and lungs. This research also sumed up the remedies and prescriptions in common use; analysed the effects of treating hyperbilirubinemia induced by viral hepatitis used in Jieduhuayuxuanfei Decoction (JDHYXF) according to the theories of TCM .The second to observe the effects of JDHYXF in treating hyperbilirubinemia induced by viral Hepatitis, 90 patients were randomlyassigned to different groups. After a month of treating, the results showed: the total effective ratio of JDHYXF group was 93.33%, higher than Jieduhuayu group and Yinzhihuang group(80%, 63.33%). JDHYXF can improve clinical symptoms, remarkably decrease the levels in blood of bilirubin, TBA, CG, HA, PCIII, LN, increase the level of TP, ALB, shorten PT, improve PTA; and decrease the levels of endotoxin and IL-l, TNF-a.The third, in order to approve effect of JDHYXF ulterior, this research also observes the effects of JDHYXF on rats given ANIT to induce acute liver injury, the results showed: JDHYXF can remarkably decrease the level in blood of bilirubin ,TBA, decrease the levels of endotoxin and TNF-a. So it can effectively control hepatic fibrosis of rats. |
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