A Discussion On Nosocomial Infection And Its Risk Factors In Patients With Acute Ieukemia

Objective: To investigate the characteristics of nosocomial infection in patients with acute leukemia and provide basis for its prevention and treatment .Methods: A retrospective review of the medical records of 311 patients with acute leukemia admitted between October, 2001 and October, 2003 was performed. 144 cases were regarded as nosocomial infection group(NI group), the other 167 cases without any infections as non-NI group. The data were analyzed with the single factor X~2 test and multifactor logistic-regression analysis.Results: The incidence of nosocomial infection was 46.3%(144/311). mainly consisting of respiratory tract, blood and oral infection. No recognized sites could be found in certain patients with nosocomial infection. The most common pathogens were gram-negative bacilli(46.6%), which were relatively sensitive to Imipenem/Cilastatin Sodium(TIENAM), Amikacin, Ceftazidine. The gram-positive cocci were relatively sensitive to Vancomycin and Ceftazidine. The analyzed results show that age, corticosteroids therapy, absolute neutrophil count in peripheral blood, cycles of chemotherapy, length of hospitalization, stages of treatment, the latest infections and seasons of hospitalization were found as independent risk factors of nosocomial infection.Conclusions: The incidence of nosocomial infection in patients with...