Studies On Apoptosis And Bcl-2/Bax Gene Expression Induced By Somatostatin Analogue In Human Hepatoma Cell Line Hepg₂

Objective Primary liver cancer (PHC) is one of the most serious malignant tumors in the world, 125 myriad people nearly die for this every year in the earth. Primary liver cancer occurs high in our country. Primary liver cancer is the third common malignant tumors occurring in China. The year-morbidity of PHC is 10 times much than the Euro-American one. According to the statistics of the Sanitary Department of China, Primary liver cancer is the second leading cause of malignant tumor death in male, the fourth in female. Hepatocellular carcinoma (HCC) is the most common type of PHC (91.5%) in China. Primary liver cancer is not easy to discover and it develop quickly. There have been short-term survivals in patients with PHC. Most patients with PHC are too late to resect in clinic. The effect of treatment with chemotherapy and radiotherapy is not better and the side effect is so big that the patients treating with chemotherapy and radiotherapy can not endure .In recent years, the suppression effect of somatostatin (SST) and somatostatin analogue on tumor has received growing attention .The effect to treat neuroendocrine tumors of the digestive system with somatostatin is satisfied [1]. Many study indicated somatoatatin can suppress the growth of many solid tumors of the digestive system , such as carcinoma of stomach , colon cancer , pancreatic cancer etc , which implicated the suppression effect is concerned with the apoptosis of tumor cells induced with somatostatin [2,3] .But the study of the effect of somatostatin on primary hepatocellular cacinoma is rare. As a synthetic analogue of the octapetide of somatostatin, octreotide (sandostatin)...